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• W1570531157 startingPage "gkv811" @default.
• W1570531157 abstract "GC skew is a measure of the strand asymmetry in the distribution of guanines and cytosines. GC skew favors R-loops, a type of three stranded nucleic acid structures that form upon annealing of an RNA strand to one strand of DNA, creating a persistent RNA:DNA hybrid. Previous studies show that GC skew is prevalent at thousands of human CpG island (CGI) promoters and transcription termination regions, which correspond to hotspots of R-loop formation. Here, we investigated the conservation of GC skew patterns in 60 sequenced chordates genomes. We report that GC skew is a conserved sequence characteristic of the CGI promoter class in vertebrates. Furthermore, we reveal that promoter GC skew peaks at the exon 1/ intron1 junction and that it is highly correlated with gene age and CGI promoter strength. Our data also show that GC skew is predictive of unmethylated CGI promoters in a range of vertebrate species and that it imparts significant DNA hypomethylation for promoters with intermediate CpG densities. Finally, we observed that terminal GC skew is conserved for a subset of vertebrate genes that tend to be located significantly closer to their downstream neighbors, consistent with a role for R-loop formation in transcription termination." @default.
• W1570531157 created "2016-06-24" @default.
• W1570531157 creator A5021210092 @default.
• W1570531157 creator A5067350146 @default.
• W1570531157 creator A5081619085 @default.
• W1570531157 date "2015-08-07" @default.
• W1570531157 modified "2023-10-06" @default.
• W1570531157 title "GC skew is a conserved property of unmethylated CpG island promoters across vertebrates" @default.
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• W1570531157 doi "https://doi.org/10.1093/nar/gkv811" @default.
• W1570531157 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4787789" @default.
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• W1570531157 hasPublicationYear "2015" @default.
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