FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1570531710> ?p ?o ?g. }

• W1570531710 abstract "Background: Intracerebral hemorrhage (ICH) is the stroke subtype with the worst prognosis and has no established acute treatment. ICH is classified as lobar and non-lobar based on the location of the hemorrhage, with genetic variation contributing to risk of both subtypes. We report the first genome wide association study (GWAS) of this condition. Methods: The discovery phase included GWAS data (Illumina 610 or Affymetrix 6.0) from 6 ICH studies that enrolled subjects of European ancestry in the US and Europe. Cases were classified as lobar or non-lobar ICH based on head CT. ICH-free controls were selected from ambulatory clinics or by random digit dialing. Standard quality controls filters were applied and principal component analysis was used to account for population structure. Unobserved genotypes were inferred by imputation to 1000 genomes references panels. Association testing was carried out using logistic regression, assuming additive effects, and including age, gender and principal components in the model. Meta-analyses were completed using the inverse normal method, weighting by sample size. Replication of signals with p<1x10E-6 was pursued in an independent multi-ethnic study utilizing direct genotyping. Results: The discovery phase included 1545 cases (664 lobar and 881 non-lobar) and 1481 controls, and tested 5,358,103 SNPs. Two loci were identified: for lobar ICH, an intergenic region located on chromosome 12q21.1 (rs11179580: minor allele frequency [MAF] 0.22, OR 1.54, 95% CI 1.33 - 1.84; p = 6.7x10E-8); and for non-lobar ICH, a region on chromosome 1q22 encompassing the PMF1 and SLC25A44 genes (rs2984613: MAF 0.31, OR 1.45, 95% CI 1.2 - 1.64; p = 8.9x10E-9). Replication included 1256 cases (329 whites, 506 blacks and 421 Hispanics) and 760 controls (237 whites, 346 blacks and 177 Hispanics) and confirmed both loci: 12q21.1 (p = 0.037, meta-analysis p = 2.3x10E-8) and 1q22 (p = 3.0x10E-4, meta-analysis p = 2.2x10E-11). Conclusions: Two new susceptibility loci for ICH were identified, both showing location-specificity. These results confirm the presence of biological heterogeneity across ICH subtypes and highlight that different genetic risk factors may contribute to the small vessel diseases that underlie each ICH subtype." @default.
• W1570531710 created "2016-06-24" @default.
• W1570531710 creator A5004416193 @default.
• W1570531710 creator A5006664647 @default.
• W1570531710 creator A5010722813 @default.
• W1570531710 creator A5010953822 @default.
• W1570531710 creator A5018531683 @default.
• W1570531710 creator A5023456800 @default.
• W1570531710 creator A5030650722 @default.
• W1570531710 creator A5036911759 @default.
• W1570531710 creator A5038372761 @default.
• W1570531710 creator A5038918342 @default.
• W1570531710 creator A5042119710 @default.
• W1570531710 creator A5047807086 @default.
• W1570531710 creator A5049358985 @default.
• W1570531710 creator A5052768521 @default.
• W1570531710 creator A5053098139 @default.
• W1570531710 creator A5057831328 @default.
• W1570531710 creator A5061123357 @default.
• W1570531710 creator A5062194357 @default.
• W1570531710 creator A5063509357 @default.
• W1570531710 creator A5063673987 @default.
• W1570531710 creator A5064334744 @default.
• W1570531710 creator A5067654386 @default.
• W1570531710 creator A5071319528 @default.
• W1570531710 creator A5075877585 @default.
• W1570531710 creator A5083998884 @default.
• W1570531710 creator A5084686950 @default.
• W1570531710 creator A5084987336 @default.
• W1570531710 creator A5086563558 @default.
• W1570531710 creator A5086779516 @default.
• W1570531710 date "2014-02-01" @default.
• W1570531710 modified "2023-09-30" @default.
• W1570531710 title "Abstract 181: Meta-Analysis of Genome-Wide Association Studies Identifies Two New Susceptibility Loci for Intracerebral Hemorrhage" @default.
• W1570531710 doi "https://doi.org/10.1161/str.45.suppl_1.181" @default.
• W1570531710 hasPublicationYear "2014" @default.
• W1570531710 type Work @default.
• W1570531710 sameAs 1570531710 @default.
• W1570531710 citedByCount "0" @default.
• W1570531710 crossrefType "journal-article" @default.
• W1570531710 hasAuthorship W1570531710A5004416193 @default.
• W1570531710 hasAuthorship W1570531710A5006664647 @default.
• W1570531710 hasAuthorship W1570531710A5010722813 @default.
• W1570531710 hasAuthorship W1570531710A5010953822 @default.
• W1570531710 hasAuthorship W1570531710A5018531683 @default.
• W1570531710 hasAuthorship W1570531710A5023456800 @default.
• W1570531710 hasAuthorship W1570531710A5030650722 @default.
• W1570531710 hasAuthorship W1570531710A5036911759 @default.
• W1570531710 hasAuthorship W1570531710A5038372761 @default.
• W1570531710 hasAuthorship W1570531710A5038918342 @default.
• W1570531710 hasAuthorship W1570531710A5042119710 @default.
• W1570531710 hasAuthorship W1570531710A5047807086 @default.
• W1570531710 hasAuthorship W1570531710A5049358985 @default.
• W1570531710 hasAuthorship W1570531710A5052768521 @default.
• W1570531710 hasAuthorship W1570531710A5053098139 @default.
• W1570531710 hasAuthorship W1570531710A5057831328 @default.
• W1570531710 hasAuthorship W1570531710A5061123357 @default.
• W1570531710 hasAuthorship W1570531710A5062194357 @default.
• W1570531710 hasAuthorship W1570531710A5063509357 @default.
• W1570531710 hasAuthorship W1570531710A5063673987 @default.
• W1570531710 hasAuthorship W1570531710A5064334744 @default.
• W1570531710 hasAuthorship W1570531710A5067654386 @default.
• W1570531710 hasAuthorship W1570531710A5071319528 @default.
• W1570531710 hasAuthorship W1570531710A5075877585 @default.
• W1570531710 hasAuthorship W1570531710A5083998884 @default.
• W1570531710 hasAuthorship W1570531710A5084686950 @default.
• W1570531710 hasAuthorship W1570531710A5084987336 @default.
• W1570531710 hasAuthorship W1570531710A5086563558 @default.
• W1570531710 hasAuthorship W1570531710A5086779516 @default.
• W1570531710 hasConcept C104317684 @default.
• W1570531710 hasConcept C106208931 @default.
• W1570531710 hasConcept C126322002 @default.
• W1570531710 hasConcept C135763542 @default.
• W1570531710 hasConcept C153209595 @default.
• W1570531710 hasConcept C157410074 @default.
• W1570531710 hasConcept C186413461 @default.
• W1570531710 hasConcept C2777094939 @default.
• W1570531710 hasConcept C2777736543 @default.
• W1570531710 hasConcept C2908647359 @default.
• W1570531710 hasConcept C31467283 @default.
• W1570531710 hasConcept C54355233 @default.
• W1570531710 hasConcept C71924100 @default.
• W1570531710 hasConcept C86803240 @default.
• W1570531710 hasConcept C99454951 @default.
• W1570531710 hasConceptScore W1570531710C104317684 @default.
• W1570531710 hasConceptScore W1570531710C106208931 @default.
• W1570531710 hasConceptScore W1570531710C126322002 @default.
• W1570531710 hasConceptScore W1570531710C135763542 @default.
• W1570531710 hasConceptScore W1570531710C153209595 @default.
• W1570531710 hasConceptScore W1570531710C157410074 @default.
• W1570531710 hasConceptScore W1570531710C186413461 @default.
• W1570531710 hasConceptScore W1570531710C2777094939 @default.
• W1570531710 hasConceptScore W1570531710C2777736543 @default.
• W1570531710 hasConceptScore W1570531710C2908647359 @default.
• W1570531710 hasConceptScore W1570531710C31467283 @default.
• W1570531710 hasConceptScore W1570531710C54355233 @default.
• W1570531710 hasConceptScore W1570531710C71924100 @default.
• W1570531710 hasConceptScore W1570531710C86803240 @default.
• W1570531710 hasConceptScore W1570531710C99454951 @default.
• W1570531710 hasIssue "suppl_1" @default.

• next