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• W1570532972 abstract "We report two patients with a myelodysplastic syndrome and the Philadelphia (Ph) chromosome. The first patient was a 73-year-old man who was diagnosed as having a chronic myelomonocytic leukemia in combination with features suggestive of a myeloproliferative syndrome. Chromosomal analysis showed a normal karyotype in the majority of cells, mixed with metaphases containing a standard Ph translocation, t(9;22)(q34;q11), as well as a translocation between chromosome 4 and 6: t(4;6)(p15;p12). Southern blot analysis showed breakpoint cluster region rearrangement as observed in classic chronic myeloid leukemia. The second patient was a 63-year-old man with a myelodysplastic syndrome, type refractory anemia. Cytogenetic study of bone marrow cells at the time of diagnosis revealed a normal karyotype: 46,XY. The initial myelodysplastic syndrome evolved to a myeloproliferative phase with progressive leukocytosis and thrombocytosis. During the terminal phase the Ph chromosome was discovered in 100% of the examined cells. We discuss the correlation between MDS and myeloproliferative diseases, the de novo acquisition of the Ph chromosome during the course of a myelodysplastic syndrome, and review the literature." @default.
• W1570532972 created "2016-06-24" @default.
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• W1570532972 date "1992-04-01" @default.
• W1570532972 modified "2023-10-16" @default.
• W1570532972 title "Cytogenetic and molecular studies of the Philadelphia translocation in myelodysplastic syndromes" @default.
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• W1570532972 doi "https://doi.org/10.1016/0165-4608(92)90209-q" @default.
• W1570532972 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1581881" @default.
• W1570532972 hasPublicationYear "1992" @default.
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