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• W1570541441 abstract "Background Patients with type 1 diabetes often develop microvascular complications and are at increased risk of premature cardiovascular disease. Women with type 1 diabetes lack the normal female protection against cardiovascular disease and may even be at higher risk compared with men with type 1 diabetes. Development of vascular complications may in part be explained by changes in hemostatic function in type 1 diabetes. Formation of a fibrin clot is the last step of the coagulation cascade and the structure of the formed clot reflects the environment in which it is formed. Tighter and less permeable fibrin clots are more resistant against degradation and are associated with cardiovascular risk factors and disease. Aims The aims of this work were to investigate in vitro fibrin clot properties in adult patients with type 1 diabetes in relation to sex and microvascular complications (Paper I); treatment effects of high-dose atorvastatin on fibrin clot properties (Paper II) and skin microvascular reactivity (Paper III); and effects of aspirin on fibrin clot properties (Paper IV). Methods The results are based on three studies: Paper I, a descriptive study involving 236 patients (107 females) with type 1 diabetes; Papers II and III, a randomized doubleblind cross-over study in which 20 patients (10 females) with type 1 diabetes and dyslipidemia were treated daily with atorvastatin 80mg/day or placebo for two months; and Paper IV, a randomized cross-over study in which 24 patients (12 women) with good glycemic control and 24 patients (12 women) with poor glycemic control were treated with low (75 mg) and high (320 mg) doses of aspirin. Fibrin clot properties were assessed by determination of the permeability coefficient (Ks) and by turbidimetric clotting and lysis assays. Thrombin generation was investigated by assessment of plasma levels of prothrombin fragment 1+2 and tissue factor-induced thrombin formation in vitro. Plasma fibrinogen concentrations were measured by means of the Clauss method. Circulating levels of platelet and endothelial microparticles were investigated by flow cytometry. In Paper III, the effect of atorvastatin treatment on forearm skin microcirculation was investigated by way of laser Doppler perfusion imaging during iontophoresis of acetylcholine and sodium nitroprusside to assess endothelium-dependent and endothelium-independent microvascular reactivity. Various biochemical markers of endothelial function were also analyzed in this study." @default.
• W1570541441 created "2016-06-24" @default.
• W1570541441 creator A5023390914 @default.
• W1570541441 date "2013-11-28" @default.
• W1570541441 modified "2023-09-24" @default.
• W1570541441 title "Hemostasis and microvascular function in type 1 diabetes : effects of treatment with statin and aspirin" @default.
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