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• W1570552451 abstract "Small ions and molecules can traverse the nuclear pore complex (NPC) simply by diffusion, whereas larger proteins and RNAs require specific signals and factors that facilitate their passage through the NPC. Our understanding of the factors that participate and regulate nucleocytoplasmic transport has increased tremendously over the past years, whereas the actual translocation step through the NPC has remained largely unclear. Here, we present and discuss recent findings on the interaction between the NPC and transport receptors and provide new evidence that the NPC acts as a constrained diffusion pore for molecules and particles without retention signal and as an affinity gate for signal-bearing cargos." @default.
• W1570552451 created "2016-06-24" @default.
• W1570552451 creator A5031935120 @default.
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• W1570552451 date "2006-03-01" @default.
• W1570552451 modified "2023-10-01" @default.
• W1570552451 title "Getting across the nuclear pore complex: new insights into nucleocytoplasmic transportThis paper is one of a selection of papers published in this Special Issue, entitled The Nucleus: A Cell Within A Cell." @default.
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• W1570552451 doi "https://doi.org/10.1139/y06-001" @default.
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• W1570552451 hasPublicationYear "2006" @default.
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