FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1570554881> ?p ?o ?g. }

• W1570554881 endingPage "677" @default.
• W1570554881 startingPage "670" @default.
• W1570554881 abstract "From previous work, it appears that glutamate can activate the hypothalamic-pituitary-adrenocortical (HPA) axis by an interaction at either ionotopic or metabotropic (G-protein coupled) receptors. For example, (1S,3R)-1-aminocyclopentane-1,3-dicarboxylate (ACPD), a metabotropic glutamate (mGlu) receptor agonist, has been shown to increase the levels of serum corticosterone in rats. The present study was undertaken to further characterize which of the mGlu receptors are substantially involved in control of the HPA axis. The group I mGlu receptor agonists, 3,5-dihydroxyphenylglycine (DHPG), 1S,3R-ACPD, and 2-chloro-5-hydroxyphenylglycine (CHPG) but not the inactive isomer 1R,3S-ACPD were found to dose-dependently increase serum corticosterone 1 h after intracerebroventricular (i.c.v.) injection in male rats. The relative potency, DHPG (EC50 = 520 nmol) > 1S,3R-ACPD (1.4 µmol) = CHPG (2.7 µmol) ≫ 1R,3S-ACPD (≫ 3 µmol) is consistent with activation of group I (mGlu1/5) receptors. The effects of DHPG were long lasting with substantial elevations in corticosterone remaining for at least 3 h. In a similar manner, the group III mGlu receptor agonists, L-AP4 (4-phosphono-2-aminobutyric acid) and L-SOP (serine-O-phosphate), were found to increase serum corticosterone levels at 1 h. In contrast, the mGlu group II selective agonists LY354740 (10 mg/kg, i.p.) and subtype-selective doses of the group II antagonist LY341495 (1 mg/kg, i.p.) did not significantly elevate serum corticosterone. Given the group I agonists results, it was surprising to find that group I selective and mGlu1 selective antagonists given alone also increased serum corticosterone. As with the agonists, the rise in serum corticosterone with LY393675 (an mGlu1/5 antagonist, EC50 = 20 nmol, i.c.v.) and LY367385 (an mGlu1 antagonist, 325 nmol, i.c.v.) were dose-dependent and consistent with their relative affinity for the group I mGlu receptors. The selective mGlu5 antagonist MPEP [2-methyl-6-(phenylethylnyl)pyridine] increased serum cortocosterone but only at high doses (> 30 mg/kg, i.p.). A model involving the high glutamatergic tone on GABAergic interneurons in the paraventricular nucleus of the hypothalamus is discussed as a possible explanation for these results." @default.
• W1570554881 created "2016-06-24" @default.
• W1570554881 creator A5032084583 @default.
• W1570554881 creator A5034811940 @default.
• W1570554881 creator A5078986055 @default.
• W1570554881 date "2001-08-01" @default.
• W1570554881 modified "2023-10-04" @default.
• W1570554881 title "Changes in Rat Serum Corticosterone After Treatment with Metabotropic Glutamate Receptor Agonists or Antagonists" @default.
• W1570554881 cites W119380384 @default.
• W1570554881 cites W1970596941 @default.
• W1570554881 cites W1973453321 @default.
• W1570554881 cites W1977851054 @default.
• W1570554881 cites W1983652754 @default.
• W1570554881 cites W1985273741 @default.
• W1570554881 cites W1988694091 @default.
• W1570554881 cites W2016413308 @default.
• W1570554881 cites W2023415006 @default.
• W1570554881 cites W2025182351 @default.
• W1570554881 cites W2028884770 @default.
• W1570554881 cites W2029542833 @default.
• W1570554881 cites W2030816371 @default.
• W1570554881 cites W2031079134 @default.
• W1570554881 cites W2040084003 @default.
• W1570554881 cites W2059802332 @default.
• W1570554881 cites W2060678350 @default.
• W1570554881 cites W2063460846 @default.
• W1570554881 cites W2066456122 @default.
• W1570554881 cites W2068273333 @default.
• W1570554881 cites W2068912431 @default.
• W1570554881 cites W2070651657 @default.
• W1570554881 cites W2077944067 @default.
• W1570554881 cites W2081831423 @default.
• W1570554881 cites W2082049028 @default.
• W1570554881 cites W2087769138 @default.
• W1570554881 cites W2093052238 @default.
• W1570554881 cites W2336104751 @default.
• W1570554881 doi "https://doi.org/10.1046/j.1365-2826.2001.00678.x" @default.
• W1570554881 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11489083" @default.
• W1570554881 hasPublicationYear "2001" @default.
• W1570554881 type Work @default.
• W1570554881 sameAs 1570554881 @default.
• W1570554881 citedByCount "44" @default.
• W1570554881 countsByYear W15705548812012 @default.
• W1570554881 countsByYear W15705548812013 @default.
• W1570554881 countsByYear W15705548812015 @default.
• W1570554881 countsByYear W15705548812016 @default.
• W1570554881 countsByYear W15705548812021 @default.
• W1570554881 countsByYear W15705548812022 @default.
• W1570554881 crossrefType "journal-article" @default.
• W1570554881 hasAuthorship W1570554881A5032084583 @default.
• W1570554881 hasAuthorship W1570554881A5034811940 @default.
• W1570554881 hasAuthorship W1570554881A5078986055 @default.
• W1570554881 hasConcept C126322002 @default.
• W1570554881 hasConcept C134018914 @default.
• W1570554881 hasConcept C170493617 @default.
• W1570554881 hasConcept C185592680 @default.
• W1570554881 hasConcept C26702167 @default.
• W1570554881 hasConcept C2776885963 @default.
• W1570554881 hasConcept C2777603759 @default.
• W1570554881 hasConcept C2778938600 @default.
• W1570554881 hasConcept C2780352252 @default.
• W1570554881 hasConcept C49051014 @default.
• W1570554881 hasConcept C61174792 @default.
• W1570554881 hasConcept C71315377 @default.
• W1570554881 hasConcept C71924100 @default.
• W1570554881 hasConcept C86803240 @default.
• W1570554881 hasConceptScore W1570554881C126322002 @default.
• W1570554881 hasConceptScore W1570554881C134018914 @default.
• W1570554881 hasConceptScore W1570554881C170493617 @default.
• W1570554881 hasConceptScore W1570554881C185592680 @default.
• W1570554881 hasConceptScore W1570554881C26702167 @default.
• W1570554881 hasConceptScore W1570554881C2776885963 @default.
• W1570554881 hasConceptScore W1570554881C2777603759 @default.
• W1570554881 hasConceptScore W1570554881C2778938600 @default.
• W1570554881 hasConceptScore W1570554881C2780352252 @default.
• W1570554881 hasConceptScore W1570554881C49051014 @default.
• W1570554881 hasConceptScore W1570554881C61174792 @default.
• W1570554881 hasConceptScore W1570554881C71315377 @default.
• W1570554881 hasConceptScore W1570554881C71924100 @default.
• W1570554881 hasConceptScore W1570554881C86803240 @default.
• W1570554881 hasIssue "8" @default.
• W1570554881 hasLocation W15705548811 @default.
• W1570554881 hasLocation W15705548812 @default.
• W1570554881 hasOpenAccess W1570554881 @default.
• W1570554881 hasPrimaryLocation W15705548811 @default.
• W1570554881 hasRelatedWork W1570554881 @default.
• W1570554881 hasRelatedWork W1973684832 @default.
• W1570554881 hasRelatedWork W2009311043 @default.
• W1570554881 hasRelatedWork W2018255792 @default.
• W1570554881 hasRelatedWork W2018975189 @default.
• W1570554881 hasRelatedWork W2034583712 @default.
• W1570554881 hasRelatedWork W2053013201 @default.
• W1570554881 hasRelatedWork W2062464911 @default.
• W1570554881 hasRelatedWork W2066942544 @default.
• W1570554881 hasRelatedWork W2414846389 @default.
• W1570554881 hasVolume "13" @default.
• W1570554881 isParatext "false" @default.
• W1570554881 isRetracted "false" @default.

• next