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- W1570561347 abstract "Abstract SJL mice immunized with proteolipid protein (PLP) 139-151 show a gender disparity in the development of autoimmune encephalomyelitis in that only females show a chronic relapsing-remitting type of paralysis, but their underlying mechanisms are unknown. We tested the hypothesis that sex steroids differentially regulate the expansion of autoreactive T cells. To this end, we have established an in vitro system to determine the effects of sex steroids on the expansion and functions of antigen-specific T cells based on proliferation assay, major histocompatibility complex class II dextramer staining, cytokine analysis and cell viability assays. Regardless of gender, we noted that the T cell responses to PLP 139-151 were significantly lower in cells exposed to either testosterone or estradiol as compared to vehicle-treated cultures, but the threshold for hormone-sensitivity is two-fold higher in males than females. Importantly, the reduced proliferative responses were found not to be due to hormonal inhibition, rather, the hormones promoted cell death. Conversely, while, the hormones reduced the number of interferon-gamma-producing cells in both the genders, interleukin (IL)-17-producing cells were reduced only in females; whereas other cytokines, such as IL-2, IL-4, IL-10, and IL-22 remained unaltered. Taken together, the data suggest that the immunomodulatory effects of sex steroids involve multiple pathways, and cell death may be the primary underlying mechanism." @default.
- W1570561347 created "2016-06-24" @default.
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- W1570561347 date "2014-05-01" @default.
- W1570561347 modified "2023-09-25" @default.
- W1570561347 title "Delineating the mechanisms of immunomodulatory effects of sex steroids in autoreactive T cells (BA15P.219)" @default.
- W1570561347 doi "https://doi.org/10.4049/jimmunol.192.supp.179.3" @default.
- W1570561347 hasPublicationYear "2014" @default.
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