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- W1570568705 abstract "Summary We report on in vitro antifungal activity and the structure–activity relationship of diphenyl diselenide [(PhSe) 2 ] and its synthetic analogues, ( p ‐Cl‐C 6 H 4 Se) 2 , ( m ‐CF 3 ‐C 6 H 4 Se) 2 and ( p ‐CH 3 O‐C 6 H 4 Se) 2 , against 116 strains of pathogenic fungi. (PhSe) 2 showed the highest inhibitory activity against Candida albicans (minimum inhibitory concentration of 4–32 μg ml −1 ), Candida dubliniensis (2–16 μg ml −1 ), Aspergillus spp. (0.5–64 μg ml −1 ) and Fusarium spp. (2–16 μg ml −1 ). Its minimum fungicidal concentration (MFC) varied among C. albicans (4–64 μg ml −1 ), C. dubliniensis (2–32 μg ml −1 ) and Fusarium spp. (4–64 μg ml −1 ). Antifungal activity was decreased by the introduction of functional groups to the (PhSe) 2 molecule: (PhSe) 2 > ( p ‐CH 3 O‐C 6 H 4 Se) 2 > ( m ‐CF 3 ‐C 6 H 4 Se) 2 > ( p ‐Cl‐C 6 H 4 Se) 2 ." @default.
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- W1570568705 date "2011-05-25" @default.
- W1570568705 modified "2023-10-16" @default.
- W1570568705 title "In vitro antifungal evaluation and structure-activity relationship of diphenyl diselenide and synthetic analogues" @default.
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- W1570568705 doi "https://doi.org/10.1111/j.1439-0507.2010.01994.x" @default.
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