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- W1570584792 abstract "Individuals within a wild population show remarkably little morphological variation, given the amount of environmental variation they encounter during development and the amount of genetic variation within the population. This phenotypic constancy led to the proposal that individuals were somehow buffered, or canalized, against genetic and environmental variation (Waddington 1942). Clearly, such a mechanism would have important evolutionary consequences; because natural selection acts upon phenotypic variation within a population, canalization first appears to reduce the evolvability of the trait upon which it is acting (Gibson and Wagner 2000). However, canalization also reduces the effects of new mutations (which may be deleterious), potentially allowing individuals to store this genetic variation without suffering the consequences. If canalization breaks down due to genetic or environmental circumstances, then the stored genetic variation will be released, providing an additional substrate for natural selection. In this way, individuals could potentially undergo large, rapid phenotypic changes.Experiments in both Drosophila and Arabidopsis have suggested that Hsp90 (heat shock protein 90), a member of a family of proteins expressed at high temperatures (heat shock), may be an excellent candidate for bringing about canalization (Rutherford and Lindquist 1998; Queitsch et al. 2002). Several features of Hsp90 suggest that it is an evolutionary buffer, capable of hiding and then releasing genetic variation: (1) individuals heterozygous for mutations in Hsp83 (the gene encoding Hsp90) show increased levels of morphological abnormalities; (2) individuals treated with a pharmacological inhibitor of Hsp90 show severe morphological abnormalities; (3) the normal function of Hsp90 is to stabilise the tertiary structure of signal transduction molecules involved in developmental pathways; and (4) this function may be compromised by environmental factors, e.g., heat shock." @default.
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- W1570584792 date "2004-01-20" @default.
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- W1570584792 title "Channelling Evolution" @default.
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- W1570584792 doi "https://doi.org/10.1371/journal.pbio.0020019" @default.
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