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• W1570586093 abstract "Publisher Summary This chapter summarizes the oriP/EBNA1 replication system in the Epstein–Barr virus (EBV) vector, the ability of EBV vectors to engineer large artificial circular episomes replicating stably in human cells, and the gene delivery system using EBV vectors. The potential significance of gene therapy using EBV vectors is discussed in the chapter. Human cells are capable of maintaining EBV vectors with an oriP/EBNA1 system as episomes. By the development of EBV vectors persisting in human and mouse cells, the evolutionary and therapeutic studies of large human DNA in rodent genetic backgrounds has been possible. In this context, EBV vectors are also helpful in the functional analysis of human interest genes using the mouse gene-target system. The EBV is a gamma herpes virus with a 172 kb double-stranded DNA genome. The virus infects some epithelial cells by unknown mechanisms and also human B lymphocytes by binding specifically to the complement receptor, followed by receptor-mediated endocytosis. Vectors based on EBV are useful for cloning and gene expression studies in primates, because the episomal stability is well maintained. The advantages of using EBV vectors are high-level expression, episomal persistence, and large DNA insertion." @default.
• W1570586093 created "2016-06-24" @default.
• W1570586093 creator A5009533434 @default.
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• W1570586093 date "2000-01-01" @default.
• W1570586093 modified "2023-09-27" @default.
• W1570586093 title "Epstein-Barr virus vectors for gene therapy" @default.
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• W1570586093 doi "https://doi.org/10.1016/s0065-3527(00)55012-x" @default.
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