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- W1570587867 endingPage "1104" @default.
- W1570587867 startingPage "1085" @default.
- W1570587867 abstract "Publisher Summary This chapter explains that prion diseases are also called transmissible spongiform encephalopathies. It discusses that their transmission has been linked to an abnormal isoform of the prion protein. Deposition of this abnormal protein isoform in the central nervous system is also associated with the onset of pathological changes and disease progression. The second most significant change to the brain other than neurodegeneration is gliosis involving both microglia and astrocytes. The possible association between gliosis and neuronal death has been investigated using cell culture models. These models, using peptide mimics of the abnormal prion protein isoform, indicate a role for both microglia and astrocytes in the neurotoxic action of the peptide. The chapter reviews that microglia activated by the prion protein peptide release both cytokines and toxic substances, such as superoxide. The cytokines released by the microglia stimulate astroglial proliferation. Alterations in the interactions between astrocytes and neurones expose neurones to the toxicity of glutamate. Thus, a model of neuronal death in prion disease has emerged, indicating that both microglia and astrocytes can either induce or exacerbate neuronal death induced by the abnormal prion protein isoform." @default.
- W1570587867 created "2016-06-24" @default.
- W1570587867 creator A5006073901 @default.
- W1570587867 creator A5091019722 @default.
- W1570587867 date "2003-01-01" @default.
- W1570587867 modified "2023-09-27" @default.
- W1570587867 title "Role of glia in prion disease" @default.
- W1570587867 cites W11095887 @default.
- W1570587867 cites W11267032 @default.
- W1570587867 cites W149247114 @default.
- W1570587867 cites W1502562397 @default.
- W1570587867 cites W1557724928 @default.
- W1570587867 cites W1576911364 @default.
- W1570587867 cites W1581477304 @default.
- W1570587867 cites W1896952141 @default.
- W1570587867 cites W1964249554 @default.
- W1570587867 cites W1965483182 @default.
- W1570587867 cites W1969671791 @default.
- W1570587867 cites W1969892750 @default.
- W1570587867 cites W1970306306 @default.
- W1570587867 cites W1972409470 @default.
- W1570587867 cites W1973473665 @default.
- W1570587867 cites W1974433806 @default.
- W1570587867 cites W1977757584 @default.
- W1570587867 cites W1978450544 @default.
- W1570587867 cites W1978827571 @default.
- W1570587867 cites W1979059592 @default.
- W1570587867 cites W1979302187 @default.
- W1570587867 cites W1979857580 @default.
- W1570587867 cites W1980523198 @default.
- W1570587867 cites W1980735475 @default.
- W1570587867 cites W1981250435 @default.
- W1570587867 cites W1981659565 @default.
- W1570587867 cites W1983773095 @default.
- W1570587867 cites W1985134652 @default.
- W1570587867 cites W1986240789 @default.
- W1570587867 cites W1986502812 @default.
- W1570587867 cites W1987043897 @default.
- W1570587867 cites W1988861392 @default.
- W1570587867 cites W1989395013 @default.
- W1570587867 cites W1990365858 @default.
- W1570587867 cites W1991436339 @default.
- W1570587867 cites W1992599971 @default.
- W1570587867 cites W1993772386 @default.
- W1570587867 cites W1996611220 @default.
- W1570587867 cites W1998038512 @default.
- W1570587867 cites W1999613366 @default.
- W1570587867 cites W2000427115 @default.
- W1570587867 cites W2001312162 @default.
- W1570587867 cites W2005095396 @default.
- W1570587867 cites W2007242005 @default.
- W1570587867 cites W2011035634 @default.
- W1570587867 cites W2012862669 @default.
- W1570587867 cites W2013679718 @default.
- W1570587867 cites W2013763910 @default.
- W1570587867 cites W2013966508 @default.
- W1570587867 cites W2014408427 @default.
- W1570587867 cites W2022131253 @default.
- W1570587867 cites W2022295948 @default.
- W1570587867 cites W2022993326 @default.
- W1570587867 cites W2023290470 @default.
- W1570587867 cites W2025809696 @default.
- W1570587867 cites W2026534774 @default.
- W1570587867 cites W2027785700 @default.
- W1570587867 cites W2030352252 @default.
- W1570587867 cites W2031357490 @default.
- W1570587867 cites W2038887966 @default.
- W1570587867 cites W2042978244 @default.
- W1570587867 cites W2051968416 @default.
- W1570587867 cites W2052517492 @default.
- W1570587867 cites W2053148425 @default.
- W1570587867 cites W2058664657 @default.
- W1570587867 cites W2059490067 @default.
- W1570587867 cites W2061060121 @default.
- W1570587867 cites W2062354055 @default.
- W1570587867 cites W2064722614 @default.
- W1570587867 cites W2065169750 @default.
- W1570587867 cites W2065193233 @default.
- W1570587867 cites W2065604724 @default.
- W1570587867 cites W2066502546 @default.
- W1570587867 cites W2071742401 @default.
- W1570587867 cites W2072244190 @default.
- W1570587867 cites W2075442841 @default.
- W1570587867 cites W2076146345 @default.
- W1570587867 cites W2082872027 @default.
- W1570587867 cites W2084903054 @default.
- W1570587867 cites W2089246382 @default.
- W1570587867 cites W2089745167 @default.
- W1570587867 cites W2090311779 @default.
- W1570587867 cites W2091306165 @default.
- W1570587867 cites W2091431916 @default.
- W1570587867 cites W2096678988 @default.
- W1570587867 cites W2097436697 @default.
- W1570587867 cites W2098324936 @default.
- W1570587867 cites W2100611021 @default.
- W1570587867 cites W2103105379 @default.
- W1570587867 cites W2108678943 @default.
- W1570587867 cites W2110484308 @default.