Matches in SemOpenAlex for { <https://semopenalex.org/work/W157059450> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W157059450 abstract "Ghrelin is a peptide hormone involved in hunger signaling and other physiological processes. To become active, ghrelin first must be acylated by ghrelin O-acyltransferase (GOAT). This enzyme carries out a post-translational modification that attaches an octanoyl group to the side chain of the serine 3 (S3) residue of ghrelin. With ghrelin linked to hunger signaling, memory, and other physiological processes, GOAT has been identified as a potential drug target. However, inhibitor design is difficult because not much is known regarding the active site structure and catalytic mechanism of GOAT. This study reports the design of a novel fluorescence-based assay that allows the use of ghrelin substrate mimics and derivatives to interrogate ghrelin recognition by GOAT. The results of this research can directly contribute to helping in the development of novel GOAT inhibitors." @default.
- W157059450 created "2016-06-24" @default.
- W157059450 creator A5086511195 @default.
- W157059450 date "2013-01-01" @default.
- W157059450 modified "2023-09-26" @default.
- W157059450 title "Investigation of ghrelin acylation by ghrelin O-acyltransferase" @default.
- W157059450 cites W2018127398 @default.
- W157059450 cites W2059488879 @default.
- W157059450 cites W2076405667 @default.
- W157059450 cites W2077343693 @default.
- W157059450 cites W2084865295 @default.
- W157059450 cites W2085217050 @default.
- W157059450 cites W2107620313 @default.
- W157059450 cites W2148142181 @default.
- W157059450 cites W2152589533 @default.
- W157059450 cites W2163865122 @default.
- W157059450 cites W57013684 @default.
- W157059450 hasPublicationYear "2013" @default.
- W157059450 type Work @default.
- W157059450 sameAs 157059450 @default.
- W157059450 citedByCount "0" @default.
- W157059450 crossrefType "journal-article" @default.
- W157059450 hasAuthorship W157059450A5086511195 @default.
- W157059450 hasConcept C126322002 @default.
- W157059450 hasConcept C134018914 @default.
- W157059450 hasConcept C161790260 @default.
- W157059450 hasConcept C181199279 @default.
- W157059450 hasConcept C185592680 @default.
- W157059450 hasConcept C193557335 @default.
- W157059450 hasConcept C2776414213 @default.
- W157059450 hasConcept C2779357093 @default.
- W157059450 hasConcept C2781338088 @default.
- W157059450 hasConcept C55493867 @default.
- W157059450 hasConcept C71315377 @default.
- W157059450 hasConcept C71924100 @default.
- W157059450 hasConcept C86803240 @default.
- W157059450 hasConceptScore W157059450C126322002 @default.
- W157059450 hasConceptScore W157059450C134018914 @default.
- W157059450 hasConceptScore W157059450C161790260 @default.
- W157059450 hasConceptScore W157059450C181199279 @default.
- W157059450 hasConceptScore W157059450C185592680 @default.
- W157059450 hasConceptScore W157059450C193557335 @default.
- W157059450 hasConceptScore W157059450C2776414213 @default.
- W157059450 hasConceptScore W157059450C2779357093 @default.
- W157059450 hasConceptScore W157059450C2781338088 @default.
- W157059450 hasConceptScore W157059450C55493867 @default.
- W157059450 hasConceptScore W157059450C71315377 @default.
- W157059450 hasConceptScore W157059450C71924100 @default.
- W157059450 hasConceptScore W157059450C86803240 @default.
- W157059450 hasLocation W1570594501 @default.
- W157059450 hasOpenAccess W157059450 @default.
- W157059450 hasPrimaryLocation W1570594501 @default.
- W157059450 hasRelatedWork W1583503979 @default.
- W157059450 hasRelatedWork W1634991326 @default.
- W157059450 hasRelatedWork W1840092613 @default.
- W157059450 hasRelatedWork W1870832265 @default.
- W157059450 hasRelatedWork W1977161495 @default.
- W157059450 hasRelatedWork W1985541971 @default.
- W157059450 hasRelatedWork W1987484594 @default.
- W157059450 hasRelatedWork W1989144464 @default.
- W157059450 hasRelatedWork W2037548155 @default.
- W157059450 hasRelatedWork W2061950866 @default.
- W157059450 hasRelatedWork W2062367005 @default.
- W157059450 hasRelatedWork W2082077227 @default.
- W157059450 hasRelatedWork W209761738 @default.
- W157059450 hasRelatedWork W2131874634 @default.
- W157059450 hasRelatedWork W2375512619 @default.
- W157059450 hasRelatedWork W2973200450 @default.
- W157059450 hasRelatedWork W3124367098 @default.
- W157059450 hasRelatedWork W3176805496 @default.
- W157059450 hasRelatedWork W83623201 @default.
- W157059450 hasRelatedWork W2828194906 @default.
- W157059450 isParatext "false" @default.
- W157059450 isRetracted "false" @default.
- W157059450 magId "157059450" @default.
- W157059450 workType "article" @default.