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- W1570600309 endingPage "756" @default.
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- W1570600309 abstract "ABSTRACT Although multipotent cell types have enlarged nuclei with decondensed chromatin, this property has not been exploited to enhance the characterization of neural progenitor cell (NPC) populations in the brain. We found that mouse brain cell nuclei that expressed exceptionally high levels of the pan neuronal marker NeuN/FOX3 (NeuN‐High) had decondensed chromatin relative to most NeuN‐Low or NeuN‐Neg (negative) nuclei. Purified NeuN‐High nuclei expressed significantly higher levels of transcripts encoding markers of neurogenesis, neuroplasticity, and learning and memory ( ARC, BDNF, ERG1, HOMER1, NFL/NEF1, SYT1 ), subunits of chromatin modifying machinery ( SIRT1, HDAC1, HDAC2, HDAC11, KAT2B, KAT3A, KAT3B, KAT5, DMNT1, DNMT3A, Gadd45a, Gadd45b ) and markers of NPC and cell cycle activity ( BRN2, FOXG1, KLF4, c‐MYC, OCT4, PCNA, SHH, SOX2 ) relative to neuronal NeuN‐Low or to mostly non‐neuronal NeuN‐Neg nuclei. NeuN‐High nuclei expressed higher levels of HDAC1, 2, 4, and 5 proteins. The cortex, hippocampus, hypothalamus, thalamus, and nucleus accumbens contained high percentages of large decondensed NeuN‐High nuclei, while the cerebellum, and pons contained very few. NeuN‐High nuclei have the properties consistent with their being derived from extremely active neurons with elevated rates of chromatin modification and/or NPC‐like cells with multilineage developmental potential. The further analysis of decondensed neural cell nuclei should provide novel insights into neurobiology and neurodegenerative disease. © 2014 Wiley Periodicals, Inc. Develop Neurobiol 75: 738–756, 2015" @default.
- W1570600309 created "2016-06-24" @default.
- W1570600309 creator A5042738861 @default.
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- W1570600309 creator A5049286339 @default.
- W1570600309 creator A5053980877 @default.
- W1570600309 creator A5078500134 @default.
- W1570600309 date "2014-11-13" @default.
- W1570600309 modified "2023-10-16" @default.
- W1570600309 title "Characterization of brain cell nuclei with decondensed chromatin" @default.
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