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- W1570615090 abstract "This chapter discusses the mechanisms of antimetabolite cancer chemotherapy, which includes thymidine biosynthesis, purine nucleotide synthesis, ribonucleoside reductase, and Intracellular transformations of antimetabolites. An antimetabolite interferes with the formation or utilization of a normal cellular metabolite. Most antimetabolites interfere with the enzymes involved in the synthesis of new DNA, are incorporated into the newly formed DNA, or in some cases both processes are important to an agent's efficacy. As a result, many antimetabolites are derivatives of the building blocks of DNA itself, such as the nucleoside based inhibitors, or analogs of critical cofactors such as the antifolates. Antimetabolites have been useful agents in hematopoietic therapy. Three antimetabolites have been approved for clinical use: gemcitabine, capecitabine and pemetrexed. Additional oncolytic indications for some of the approved antimetabolites are in clinical trials, and other antimetabolites, including nolatrexed and decitabine, are currently undergoing Phase III study." @default.
- W1570615090 created "2016-06-24" @default.
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- W1570615090 date "2004-01-01" @default.
- W1570615090 modified "2023-09-27" @default.
- W1570615090 title "Recent Advances in Antimetabolite Cancer Chemotherapies" @default.
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- W1570615090 doi "https://doi.org/10.1016/s0065-7743(04)39013-5" @default.
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