FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1570616401> ?p ?o ?g. }

• W1570616401 endingPage "92" @default.
• W1570616401 startingPage "92" @default.
• W1570616401 abstract "PURPOSE: The prominent ATP-binding cassette (ABC) transporters ABCB1, ABCC1, and ABCG2 are involved in substance transport across physiological barriers and therefore in drug absorption, distribution, and elimination. They also mediate multi-drug resistance in cancer cells. Different flavonoids are known to interfere with different ABC transporters. Here, the effect of the furanoflavonol karanjin, a potential drug with antiglycaemic, gastroprotective, antifungal, and antibacterial effects, was investigated on ABCB1, ABCC1, and ABCG2-mediated drug transport in comparison to the flavonoids apigenin, genistein, and naringenin. METHODS: Cells expressing the relevant transporters (ABCB1: UKF-NB-3ABCB1, UKF-NB-3rVCR10; ABCC1: G62, PC-3rVCR20; ABCG2: UKF-NB-3ABCG2) were used in combination with specific fluorescent and cytotoxic ABC transporter substrates and ABC transporter inhibitors to study ABC transporter function. Moreover, the effects of the investigated flavonoids were determined on the ABC transporter ATPase activities. RESULTS: Karanjin interfered with drug efflux mediated by ABCB1, ABCC1, and ABCG2 and enhanced the ATPase activity of all three transporters. Moreover, karanjin exerted more pronounced effects than the control flavonoids apigenin, genistein, and naringenin on all three transporters. Most notably, karanjin interfered with ABCB1 at low concentrations being about 1µM. CONCLUSIONS: Taken together, these findings should be taken into account during further consideration of karanjin as a potential drug for different therapeutic indications. The effects on ABCB1, ABCC1, and ABCG2 may affect the pharmacokinetics of co-administered drugs. This article is open to POST-PUBLICATION REVIEW. Registered readers (see “For Readers”) may comment by clicking on ABSTRACT on the issue’s contents page.METHODS: Cells expressing the relevant transporters (ABCB1: UKF-NB-3ABCB1, UKF-NB-3rVCR10; ABCC1: G62, PC-3rVCR20; ABCG2: UKF-NB-3ABCG2) were used in combination with specific fluorescent and cytotoxic ABC transporter substrates and ABC transporter inhibitors to study ABC transporter function. Moreover, the effects of the investigated flavonoids were determined on the ABC transporter ATPase activities.RESULTS: Karanjin interfered with drug efflux mediated by ABCB1, ABCC1, and ABCG2 and enhanced the ATPase activity of all three transporters. Moreover, karanjin exerted more pronounced effects than the control flavonoids apigenin, genistein, and naringenin on all three transporters. Most notably, karanjin interfered with ABCB1 at low concentrations being about 1µM.CONCLUSIONS: Taken together, these findings should be taken into account during further consideration of karanjin as a potential drug for different therapeutic indications. The effects on ABCB1, ABCC1, and ABCG2 may affect the pharmacokinetics of co-administered drugs." @default.
• W1570616401 created "2016-06-24" @default.
• W1570616401 creator A5016040023 @default.
• W1570616401 creator A5016385634 @default.
• W1570616401 creator A5035073798 @default.
• W1570616401 creator A5058177040 @default.
• W1570616401 creator A5067741256 @default.
• W1570616401 creator A5074740364 @default.
• W1570616401 date "2014-03-10" @default.
• W1570616401 modified "2023-09-25" @default.
• W1570616401 title "Karanjin interferes with ABCB1, ABCC1, and ABCG2" @default.
• W1570616401 cites W16074613 @default.
• W1570616401 cites W1963896289 @default.
• W1570616401 cites W1968931590 @default.
• W1570616401 cites W1983739049 @default.
• W1570616401 cites W1987792429 @default.
• W1570616401 cites W2003227269 @default.
• W1570616401 cites W2008261132 @default.
• W1570616401 cites W2011027855 @default.
• W1570616401 cites W2022348868 @default.
• W1570616401 cites W2033767311 @default.
• W1570616401 cites W2039644513 @default.
• W1570616401 cites W2040651998 @default.
• W1570616401 cites W2057788409 @default.
• W1570616401 cites W2058052390 @default.
• W1570616401 cites W2065315198 @default.
• W1570616401 cites W2071619587 @default.
• W1570616401 cites W2084769078 @default.
• W1570616401 cites W2105697161 @default.
• W1570616401 cites W2106342078 @default.
• W1570616401 cites W2118234018 @default.
• W1570616401 cites W2126539385 @default.
• W1570616401 cites W2130409253 @default.
• W1570616401 cites W2132813761 @default.
• W1570616401 cites W2133228174 @default.
• W1570616401 cites W2157393167 @default.
• W1570616401 cites W395651281 @default.
• W1570616401 doi "https://doi.org/10.18433/j3bw2s" @default.
• W1570616401 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24735762" @default.
• W1570616401 hasPublicationYear "2014" @default.
• W1570616401 type Work @default.
• W1570616401 sameAs 1570616401 @default.
• W1570616401 citedByCount "20" @default.
• W1570616401 countsByYear W15706164012014 @default.
• W1570616401 countsByYear W15706164012015 @default.
• W1570616401 countsByYear W15706164012016 @default.
• W1570616401 countsByYear W15706164012017 @default.
• W1570616401 countsByYear W15706164012018 @default.
• W1570616401 countsByYear W15706164012020 @default.
• W1570616401 countsByYear W15706164012021 @default.
• W1570616401 countsByYear W15706164012022 @default.
• W1570616401 countsByYear W15706164012023 @default.
• W1570616401 crossrefType "journal-article" @default.
• W1570616401 hasAuthorship W1570616401A5016040023 @default.
• W1570616401 hasAuthorship W1570616401A5016385634 @default.
• W1570616401 hasAuthorship W1570616401A5035073798 @default.
• W1570616401 hasAuthorship W1570616401A5058177040 @default.
• W1570616401 hasAuthorship W1570616401A5067741256 @default.
• W1570616401 hasAuthorship W1570616401A5074740364 @default.
• W1570616401 hasBestOaLocation W15706164011 @default.
• W1570616401 hasConcept C104317684 @default.
• W1570616401 hasConcept C149011108 @default.
• W1570616401 hasConcept C185592680 @default.
• W1570616401 hasConcept C200082930 @default.
• W1570616401 hasConcept C2776848411 @default.
• W1570616401 hasConcept C2778004101 @default.
• W1570616401 hasConcept C2778609962 @default.
• W1570616401 hasConcept C2779054382 @default.
• W1570616401 hasConcept C2780035454 @default.
• W1570616401 hasConcept C44312359 @default.
• W1570616401 hasConcept C512196 @default.
• W1570616401 hasConcept C55493867 @default.
• W1570616401 hasConcept C63443662 @default.
• W1570616401 hasConcept C86803240 @default.
• W1570616401 hasConcept C98274493 @default.
• W1570616401 hasConceptScore W1570616401C104317684 @default.
• W1570616401 hasConceptScore W1570616401C149011108 @default.
• W1570616401 hasConceptScore W1570616401C185592680 @default.
• W1570616401 hasConceptScore W1570616401C200082930 @default.
• W1570616401 hasConceptScore W1570616401C2776848411 @default.
• W1570616401 hasConceptScore W1570616401C2778004101 @default.
• W1570616401 hasConceptScore W1570616401C2778609962 @default.
• W1570616401 hasConceptScore W1570616401C2779054382 @default.
• W1570616401 hasConceptScore W1570616401C2780035454 @default.
• W1570616401 hasConceptScore W1570616401C44312359 @default.
• W1570616401 hasConceptScore W1570616401C512196 @default.
• W1570616401 hasConceptScore W1570616401C55493867 @default.
• W1570616401 hasConceptScore W1570616401C63443662 @default.
• W1570616401 hasConceptScore W1570616401C86803240 @default.
• W1570616401 hasConceptScore W1570616401C98274493 @default.
• W1570616401 hasIssue "1" @default.
• W1570616401 hasLocation W15706164011 @default.
• W1570616401 hasLocation W15706164012 @default.
• W1570616401 hasLocation W15706164013 @default.
• W1570616401 hasLocation W15706164014 @default.
• W1570616401 hasOpenAccess W1570616401 @default.
• W1570616401 hasPrimaryLocation W15706164011 @default.
• W1570616401 hasRelatedWork W1570616401 @default.

• next