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• W1570648268 abstract "The metabolism and irreversible protein binding of 2,4-[3,5-3H]dimtrofluorobenzene (3H-DNFB), a model chemically reactive compound, were studied in the rat. 3H-DNFB given intravenously (5 μg, 5 mg or 25 mg per kg) to anaesthetized cannulated rats was rapidly metabolized via the mercapturic acid pathway. The metabolites were extensively eliminated in bile and urine: predominantly as the glutathione conjugate and mercapturate in bile, and as the mercapturate in urine. Only ca. 3–10% of the doses remained in the liver, kidneys, spleen, heart and lungs at 3 hr. Dinitrophenyl mercapturate was the principal urinary metabolite in conscious rats dosed i.v. (5 mg or 25 mg per kg). Only 15–25% of the radiolabelled material in liver and kidney at 3 hr was irreversibly bound to protein, but 45–99% of that in the other organs and 49–88% in plasma was irreversibly bound. Preliminary evidence for the metabolism of 3H-DNFB (5mg/kg and 25 mg/kg doses) to N2acetyl-N16-DNP-lysine, a novel conjugate and metabolite of dinitrophenylated proteins in vivo, is presented." @default.
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• W1570648268 date "1986-02-01" @default.
• W1570648268 modified "2023-09-27" @default.
• W1570648268 title "Drug-protein conjugates—X" @default.
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• W1570648268 doi "https://doi.org/10.1016/0006-2952(86)90227-3" @default.
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