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- W1570656165 abstract "Abstract Microscopic near‐infrared (NIR) spectroscopy can provide low‐level matrix information on the composition and distribution of ingredients within an intact pharmaceutical blend or tablet. NIR spectral data can be collected either by point‐by‐point spectral acquisitions (point mapping) or by global illumination of the sample (global imaging) and by image collection at individual wavelengths. On combination, these wavelength images create a hyperspectral data cube, whereby following a defined pixel through the data cube gives rise to an NIR spectrum. Therefore, both techniques provide similar information with both the spectral and spatial characteristics of the sample obtained. Microscopic NIR has potential applications for pharmaceutical analysis, although there are on‐going discussions about appropriate analysis conditions and the actual contributing volume to a single spectrum. The latter obviously impacts spectral interpretation, and as such a wide range of analysis tools are used to obtain a chemical image. Using microscopic NIR, four different pharmaceutical issues have been examined, from pretabletting blends through final dosage forms. By use of multivariate and image analysis methods it has been possible to extract useful chemical information and create ‘visual’ images of the sample. These images provide information on the size, shape, and distribution of each component within the formulation. This information has been utilized in studies of flow issues, tablet sticking and chipping during manufacture, and understanding moisture uptake in dosage forms. Microscopic NIR has been used to improve knowledge and understanding of pharmaceutical processes and potentially, with increased acquisition and processing time, could be used to control pharmaceutical production." @default.
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- W1570656165 date "2001-12-20" @default.
- W1570656165 modified "2023-10-03" @default.
- W1570656165 title "Near‐Infrared Microspectroscopy" @default.
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- W1570656165 doi "https://doi.org/10.1002/0470027320.s2603" @default.
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