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• W1570663230 endingPage "30" @default.
• W1570663230 startingPage "18" @default.
• W1570663230 abstract "This chapter discusses the biochemistry and pharmacology of antidepressives and stimulants. The synthesis and pharmacological evaluation of numerous potential antidepressives are presented. An amitriptyline derivative, exhibited a pharmacological profile similar to that of the parent. Antidepressive and antianxiety properties were also noted for a monomethyl analog. A dibenzthiepin, dothiepin, was superior to amitriptyline in a double blind comparison for the treatment of depression. Amoxapine, a dibenzoxazepine, although devoid of anticholinergic properties, produced imipramine-like activity in animals. Structure versus anti-depressive activity relationships were reported for a series of phenothiazines and related compounds bearing a carbocyclic basic side chain. The phenothiazines with antidepressive actions included the l-chloro-analog of chlorpromazine, which produced imipramine-like actions in mice and rats, and the azaphenothiazine-10-thiolcarboxylate, which induced antidepressive-like symptoms in mice. The antidepressive effects of phenothiazine derivatives with 1- or α-substituents may be associated with the steric influence of these groups in interfering with attainment of a nearly flat conformation by the tricyclic system." @default.
• W1570663230 created "2016-06-24" @default.
• W1570663230 creator A5061375864 @default.
• W1570663230 creator A5091366924 @default.
• W1570663230 date "1972-01-01" @default.
• W1570663230 modified "2023-09-25" @default.
• W1570663230 title "Chapter 2. Antidepressives and Stimulants" @default.
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