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• W1570676844 abstract "Advances in molecular phylogenetics have enabled reconstruction of the most likely chronology of events in prokaryotic evolution and correlation with the paleontologic record with increasing precision. Mycoplasmas probably evolved from clostridial ancestors by genome reduction leading to obligate parasitism of host cells. The vertebrate hosts present at the time of the origin of mycoplasmas about 400 million years ago were fish, and later amphibians and reptiles, whose descendants possess most elements of vertebrate innate and adaptive immunity. Successful colonization of those poikilothermous (cold-blooded) hosts must have involved adaptation to those defenses, shaping mycoplasma-host interactions for more than 125 million years before the earliest emergence of mammals. That history illuminates one aspect of the potential significance of mycoplasmosis of poikilothermous vertebrates to health and disease of other hosts including humans." @default.
• W1570676844 created "2016-06-24" @default.
• W1570676844 creator A5041697462 @default.
• W1570676844 date "2002-01-01" @default.
• W1570676844 modified "2023-10-17" @default.
• W1570676844 title "Mycoplasmosis and immunity of fish and reptiles" @default.
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• W1570676844 doi "https://doi.org/10.2741/a844" @default.
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