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- W1570684889 abstract "This paper presents a novel method of multi-drug scheduling using multi-objective genetic algorithm (MOGA) that can find suitable/optimum dosages by trading-off between cell killing and toxic side-effects of chemotherapy treatment. A close-loop control method, namely Integral-Proportional-Derivative (I-PD) is designed to control dosages of drugs to be infused to the patient’s body and MOGA is used to find suitable parameters of the controller. A cell compartments model is developed and used to describe the effects of the drugs on different type of cells, plasma drug concentration and toxic side-effects. Results show that specific drug schedule obtained through the proposed method can reduce the tumour size nearly 100% with relatively lower toxic side-effects." @default.
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- W1570684889 date "2011-01-01" @default.
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- W1570684889 title "MOGA-Based Multi-drug Optimisation for Cancer Chemotherapy" @default.
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- W1570684889 doi "https://doi.org/10.1007/978-3-642-19914-1_19" @default.
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