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- W1570708274 abstract "The scavenger receptor A-I/II (SRA-I/II) on alveolar macrophages is involved in recognition and clearance of modified lipids and inhaled particulates. A rare variant of the SRA-I/II gene, A293X, truncates the distal collagen-like domain, which is essential for ligand recognition. We tested whether the A293X variant is associated with reduced lung function and risk of COPD in the general population. We genotyped 48,741 individuals from the adult Danish general population for Arg293X, and recorded lung function and spirometry-defined COPD. Arg293X homozygotes (n = 5) and heterozygotes (n = 587) vs noncarriers (n = 48,149) had 6% and 1% reduced FVC%predicted (p = 0.05) and trends of 7% and 1% reduced FEV1%predicted (p = 0.06). The Arg293X genotype interacted with gender (p = 0.004) and α1-antitrypsin MZ heterozygosity (p = 0.049) in predicting FEV1%predicted, but not with superoxide dismutase-3 E1I1 heterozygosity (p = 0.11). Among men, Arg293X heterozygotes had 4% reduced FEV1%predicted (p = 0.0004) and 4% reduced FVC%predicted (p = 0.0003) compared with noncarriers. Corresponding values were 14% (p = 0.03) and 11% (p = 0.04) among MZ heterozygotes, and 9% (p = 0.03) and 8% (p = 0.04) among E1I1 heterozygotes. Arg293X heterozygotes did not differ from noncarriers in lung function among females, or individuals without MZ and E1I1. Arg293X heterozygosity was associated with spirometry-defined COPD among men (odds ratio and 95%CI: 1.7(1.1– 2.4)), but not with COPD overall or in any other subgroup. Scavenger receptor AI/II Arg293X heterozygotes have reduced lung function and increased COPD risk among men. They also have reduced lung function among individuals heterozygous for the α1-antitrypsin MZ and superoxide dismutase-3 E1I1 genotypes." @default.
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- W1570708274 date "2011-09-20" @default.
- W1570708274 modified "2023-10-14" @default.
- W1570708274 title "Scavenger receptor AI/II truncation, lung function and COPD in 48,700 individuals" @default.
- W1570708274 doi "https://doi.org/10.1111/j.1752-699x.2011.00266_3.x" @default.
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