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• W1570729614 abstract "Connexin43 (Cx43) is one of the most abundant gap junction proteins in the central nervous system. Abnormal opening of Cx43 hemichannels after ischemic insults causes apoptotic cell death. In this study, we found persistently increased expression of Cx43 8 h to 7 d after hypoxia/ischemia (HI) injury in neonatal rats. Pre-treatment with Gap26 and Gap27, two Cx43 mimetic peptides, significantly reduced cerebral infarct volume. Gap26 treatment at 24 h after ischemia improved functional recovery on muscle strength, motor coordination, and spatial memory abilities. Further, Gap26 inhibited Cx43 expression and reduced active astrogliosis. Gap26 interacted and co-localized with Cx43 together in brain tissues and cultured astrocytes. After oxygen glucose deprivation, Gap26 treatment reduced the total Cx43 level in cultured astrocytes; but Cx43 level in the plasma membrane was increased. Degradation of Cx43 in the cytoplasm was mainly via the ubiquitin proteasome pathway. Concurrently, phosphorylated Akt, which phosphorylates Cx43 on Serine(373) and facilitates the forward transport of Cx43 to the plasma membrane, was increased by Gap26 treatment. Microdialysis showed that increased membranous Cx43 causes glutamate release by opening Cx43 hemichannels. Extracellular glutamate concentration was significantly decreased by Gap26 treatment in vivo. Finally, we found that cleaved caspase-3, an apoptosis marker, was attenuated after HI injury by Gap26 treatment. Effects of Gap27 were analogous to those of Gap26. In summary, our findings demonstrate that modulation of Cx43 expression and astroglial function is a potential therapeutic strategy for ischemic brain injury." @default.
• W1570729614 created "2016-06-24" @default.
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• W1570729614 date "2015-05-19" @default.
• W1570729614 modified "2023-10-17" @default.
• W1570729614 title "Inhibition of connexin43 improves functional recovery after ischemic brain injury in neonatal rats" @default.
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• W1570729614 cites W1967061503 @default.
• W1570729614 cites W1967354672 @default.
• W1570729614 cites W1968922340 @default.
• W1570729614 cites W1969058470 @default.
• W1570729614 cites W1969183124 @default.
• W1570729614 cites W1973975054 @default.
• W1570729614 cites W1978118346 @default.
• W1570729614 cites W1978254950 @default.
• W1570729614 cites W1982952381 @default.
• W1570729614 cites W1984011321 @default.
• W1570729614 cites W1988086690 @default.
• W1570729614 cites W1992576846 @default.
• W1570729614 cites W1997215245 @default.
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• W1570729614 cites W2005419084 @default.
• W1570729614 cites W2007854449 @default.
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• W1570729614 cites W2020025443 @default.
• W1570729614 cites W2028798690 @default.
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• W1570729614 cites W2064197300 @default.
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• W1570729614 cites W2083348911 @default.
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• W1570729614 doi "https://doi.org/10.1002/glia.22826" @default.
• W1570729614 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25988944" @default.
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