FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1570731639> ?p ?o ?g. }

• W1570731639 endingPage "2228" @default.
• W1570731639 startingPage "2221" @default.
• W1570731639 abstract "Alloantibody is an important effector mechanism for allograft rejection. In this study, we tested the hypothesis that regulatory T cells with indirect allospecificity can prevent humoral rejection by using a rat transplant model in which acute rejection of MHC class I-disparate PVG.R8 heart grafts by PVG.RT1(u) recipients is mediated by alloantibody and is dependent upon help from CD4 T cells that can recognize the disparate MHC alloantigen only via the indirect pathway. Pretransplant treatment of PVG.RT1(u) recipients with anti-CD4 mAb plus donor-specific transfusion abrogated alloantibody production and prolonged PVG.R8 graft survival indefinitely. Naive syngeneic splenocytes injected into tolerant animals did not effect heart graft rejection, suggesting the presence of regulatory mechanisms. Adoptive transfer experiments into CD4 T cell-reconstituted, congenitally athymic recipients confirmed that regulation was mediated by CD4 T cells and was alloantigen-specific. CD4 T cell regulation could be broken in tolerant animals either by immunizing with an immunodominant linear allopeptide or by depleting tolerant CD4 T cells, but surprisingly this resulted in neither alloantibody generation nor graft rejection. These findings demonstrate that anti-CD4 plus donor-specific transfusion treatment results in the development of CD4 regulatory T cells that recognize alloantigens via the indirect pathway and act in an Ag-specific manner to prevent alloantibody-mediated rejection. Their development is associated with intrinsic tolerance within the alloantigen-specific B cell compartment that persists after T cell help is made available." @default.
• W1570731639 created "2016-06-24" @default.
• W1570731639 creator A5001008330 @default.
• W1570731639 creator A5003640755 @default.
• W1570731639 creator A5050004336 @default.
• W1570731639 creator A5054617785 @default.
• W1570731639 creator A5058370603 @default.
• W1570731639 creator A5060013229 @default.
• W1570731639 creator A5080216172 @default.
• W1570731639 date "2007-02-15" @default.
• W1570731639 modified "2023-09-25" @default.
• W1570731639 title "Abrogation of Antibody-Mediated Allograft Rejection by Regulatory CD4 T Cells with Indirect Allospecificity" @default.
• W1570731639 cites W1494432631 @default.
• W1570731639 cites W1509909867 @default.
• W1570731639 cites W1512452047 @default.
• W1570731639 cites W1525863788 @default.
• W1570731639 cites W1553215445 @default.
• W1570731639 cites W1560633215 @default.
• W1570731639 cites W1606280569 @default.
• W1570731639 cites W1815644294 @default.
• W1570731639 cites W1936576945 @default.
• W1570731639 cites W1958962606 @default.
• W1570731639 cites W1964935551 @default.
• W1570731639 cites W1975078601 @default.
• W1570731639 cites W1980897542 @default.
• W1570731639 cites W1984186890 @default.
• W1570731639 cites W1991778725 @default.
• W1570731639 cites W1992115816 @default.
• W1570731639 cites W1995138538 @default.
• W1570731639 cites W1997244864 @default.
• W1570731639 cites W2000411875 @default.
• W1570731639 cites W2010565041 @default.
• W1570731639 cites W2017237052 @default.
• W1570731639 cites W2021257197 @default.
• W1570731639 cites W2023264003 @default.
• W1570731639 cites W2042844150 @default.
• W1570731639 cites W2047800220 @default.
• W1570731639 cites W2056457826 @default.
• W1570731639 cites W2058115325 @default.
• W1570731639 cites W2058232542 @default.
• W1570731639 cites W2063966481 @default.
• W1570731639 cites W2067739721 @default.
• W1570731639 cites W2068238618 @default.
• W1570731639 cites W2069701927 @default.
• W1570731639 cites W2074640102 @default.
• W1570731639 cites W2076104117 @default.
• W1570731639 cites W2078365253 @default.
• W1570731639 cites W2087976968 @default.
• W1570731639 cites W2095589644 @default.
• W1570731639 cites W2099318980 @default.
• W1570731639 cites W2101211522 @default.
• W1570731639 cites W2102106323 @default.
• W1570731639 cites W2107104928 @default.
• W1570731639 cites W2111344966 @default.
• W1570731639 cites W2114412297 @default.
• W1570731639 cites W2117412758 @default.
• W1570731639 cites W2118102164 @default.
• W1570731639 cites W2127293742 @default.
• W1570731639 cites W2131937708 @default.
• W1570731639 cites W2140791963 @default.
• W1570731639 cites W2149123553 @default.
• W1570731639 cites W2158558790 @default.
• W1570731639 cites W2159346740 @default.
• W1570731639 cites W2167318411 @default.
• W1570731639 cites W2169233545 @default.
• W1570731639 cites W2169720730 @default.
• W1570731639 cites W2792745638 @default.
• W1570731639 cites W4313333810 @default.
• W1570731639 cites W4313343356 @default.
• W1570731639 doi "https://doi.org/10.4049/jimmunol.178.4.2221" @default.
• W1570731639 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17277127" @default.
• W1570731639 hasPublicationYear "2007" @default.
• W1570731639 type Work @default.
• W1570731639 sameAs 1570731639 @default.
• W1570731639 citedByCount "42" @default.
• W1570731639 countsByYear W15707316392012 @default.
• W1570731639 countsByYear W15707316392013 @default.
• W1570731639 countsByYear W15707316392014 @default.
• W1570731639 countsByYear W15707316392015 @default.
• W1570731639 countsByYear W15707316392016 @default.
• W1570731639 countsByYear W15707316392017 @default.
• W1570731639 countsByYear W15707316392018 @default.
• W1570731639 countsByYear W15707316392019 @default.
• W1570731639 countsByYear W15707316392020 @default.
• W1570731639 countsByYear W15707316392021 @default.
• W1570731639 countsByYear W15707316392022 @default.
• W1570731639 crossrefType "journal-article" @default.
• W1570731639 hasAuthorship W1570731639A5001008330 @default.
• W1570731639 hasAuthorship W1570731639A5003640755 @default.
• W1570731639 hasAuthorship W1570731639A5050004336 @default.
• W1570731639 hasAuthorship W1570731639A5054617785 @default.
• W1570731639 hasAuthorship W1570731639A5058370603 @default.
• W1570731639 hasAuthorship W1570731639A5060013229 @default.
• W1570731639 hasAuthorship W1570731639A5080216172 @default.
• W1570731639 hasBestOaLocation W15707316391 @default.
• W1570731639 hasConcept C126322002 @default.
• W1570731639 hasConcept C147483822 @default.
• W1570731639 hasConcept C189976730 @default.

• next