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- W1570736321 abstract "Ligation of the pancreatic duct in rabbits provokes a decrease in the insulin and glucagon content of the pancreas, and may lead to chronic hyperglycemia. The insulin secretory behavior of the perfused pancreas is perturbed in duct-ligated animals, and this is illustrated in several respects: The perturbation of the anomeric specificity in secretory response is most obvious in diabetic duct-ligated rabbits, in which case β-D-glucose stimulates insulin release more efficiently than α-D-glucose. In both control and duct-ligated rabbits, however, the α-anomer is more potent than the β-anomer in suppressing leucine-stimulated glucagon secretion. These findings are compatible with the view that chronic hyperglycemia leads to alteration in the anomeric preference of the pancreatic B-cell for α-D-glucose, possibly as a result of the nonenzymatic glycation of glycolytic enzymes in insulin-producing, but not glucagon-producing, islet cells." @default.
- W1570736321 created "2016-06-24" @default.
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- W1570736321 date "1991-02-01" @default.
- W1570736321 modified "2023-09-25" @default.
- W1570736321 title "Altered anomeric specificity of glucose-induced insulin release in rabbits with duct-ligated pancreas" @default.
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- W1570736321 doi "https://doi.org/10.1007/bf02924429" @default.
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