FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1570750002> ?p ?o ?g. }

• W1570750002 endingPage "e0127236" @default.
• W1570750002 startingPage "e0127236" @default.
• W1570750002 abstract "Background Osteosarcoma is the most frequent type of malignant bone tumor in children and adolescents and is associated with a high propensity for lung metastasis. Recent experiments have indicated that PLA2G16 contributes to osteosarcoma progression and metastasis in both mouse and human osteosarcoma cell lines. The aim of this study was to compare the expression of PLA2G16 in non-metastatic and metastatic osteosarcomas to determine whether PLA2G16 expression can serve as a biomarker of osteosarcoma prognosis and metastasis. Methods Quantitative real-time PCR was used to examine PLA2G16 mRNA in primary osteosarcoma patients (18 patients without metastases and 17 patients with metastases), and immunohistochemistry (IHC) staining of PLA2G16 was performed on tissue microarrays from 119 osteosarcoma patients. Tumor metastatic behavior and survival of the patients were followed up for a minimum of 36 months and a maximum of 171 months. The prognostic value of PLA2G16 expression was evaluated by the Kaplan–Meier method and a log-rank test. Multivariate Cox regression analysis was used to identify significant independent prognostic factors. Results Osteosarcoma patients with metastasis showed a higher expression of PLA2G16 at both the mRNA and protein levels (both at P values< 0.05) than did patients without metastasis. Osteosarcoma patients with positive IHC staining of PLA2G16 expression at primary sites had shorter overall survival and metastasis-free survival (both at P values <0.02). Moreover, multivariate Cox analysis identified PLA2G16 expression as an independent prognostic factor to predict poor overall survival and metastasis-free survival (both P values < 0.03). Conclusions This study indicated that PLA2G16 expression is a significant prognostic factor in primary osteosarcoma patients for predicting the development of metastases and poor survival." @default.
• W1570750002 created "2016-06-24" @default.
• W1570750002 creator A5002545642 @default.
• W1570750002 creator A5014012741 @default.
• W1570750002 creator A5017190999 @default.
• W1570750002 creator A5030220907 @default.
• W1570750002 creator A5033469636 @default.
• W1570750002 creator A5038260886 @default.
• W1570750002 creator A5046383322 @default.
• W1570750002 creator A5048537006 @default.
• W1570750002 creator A5049646905 @default.
• W1570750002 creator A5051452798 @default.
• W1570750002 creator A5077819266 @default.
• W1570750002 creator A5091480590 @default.
• W1570750002 date "2015-05-18" @default.
• W1570750002 modified "2023-10-18" @default.
• W1570750002 title "PLA2G16 Expression in Human Osteosarcoma Is Associated with Pulmonary Metastasis and Poor Prognosis" @default.
• W1570750002 cites W1484947161 @default.
• W1570750002 cites W1977291134 @default.
• W1570750002 cites W1986409119 @default.
• W1570750002 cites W1992203600 @default.
• W1570750002 cites W2018001656 @default.
• W1570750002 cites W2019491412 @default.
• W1570750002 cites W2022676277 @default.
• W1570750002 cites W2034155469 @default.
• W1570750002 cites W2040942138 @default.
• W1570750002 cites W2042655206 @default.
• W1570750002 cites W2045016464 @default.
• W1570750002 cites W2057723954 @default.
• W1570750002 cites W2059273277 @default.
• W1570750002 cites W2076836237 @default.
• W1570750002 cites W2097892072 @default.
• W1570750002 cites W2100980533 @default.
• W1570750002 cites W2107315486 @default.
• W1570750002 cites W2109838283 @default.
• W1570750002 cites W2123018120 @default.
• W1570750002 cites W2127624416 @default.
• W1570750002 cites W2144123285 @default.
• W1570750002 cites W2152064969 @default.
• W1570750002 cites W2312392465 @default.
• W1570750002 cites W4235565063 @default.
• W1570750002 doi "https://doi.org/10.1371/journal.pone.0127236" @default.
• W1570750002 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4436297" @default.
• W1570750002 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25993412" @default.
• W1570750002 hasPublicationYear "2015" @default.
• W1570750002 type Work @default.
• W1570750002 sameAs 1570750002 @default.
• W1570750002 citedByCount "18" @default.
• W1570750002 countsByYear W15707500022015 @default.
• W1570750002 countsByYear W15707500022016 @default.
• W1570750002 countsByYear W15707500022017 @default.
• W1570750002 countsByYear W15707500022018 @default.
• W1570750002 countsByYear W15707500022019 @default.
• W1570750002 countsByYear W15707500022020 @default.
• W1570750002 countsByYear W15707500022021 @default.
• W1570750002 countsByYear W15707500022022 @default.
• W1570750002 countsByYear W15707500022023 @default.
• W1570750002 crossrefType "journal-article" @default.
• W1570750002 hasAuthorship W1570750002A5002545642 @default.
• W1570750002 hasAuthorship W1570750002A5014012741 @default.
• W1570750002 hasAuthorship W1570750002A5017190999 @default.
• W1570750002 hasAuthorship W1570750002A5030220907 @default.
• W1570750002 hasAuthorship W1570750002A5033469636 @default.
• W1570750002 hasAuthorship W1570750002A5038260886 @default.
• W1570750002 hasAuthorship W1570750002A5046383322 @default.
• W1570750002 hasAuthorship W1570750002A5048537006 @default.
• W1570750002 hasAuthorship W1570750002A5049646905 @default.
• W1570750002 hasAuthorship W1570750002A5051452798 @default.
• W1570750002 hasAuthorship W1570750002A5077819266 @default.
• W1570750002 hasAuthorship W1570750002A5091480590 @default.
• W1570750002 hasBestOaLocation W15707500021 @default.
• W1570750002 hasConcept C10515644 @default.
• W1570750002 hasConcept C121608353 @default.
• W1570750002 hasConcept C126322002 @default.
• W1570750002 hasConcept C142724271 @default.
• W1570750002 hasConcept C143998085 @default.
• W1570750002 hasConcept C193270364 @default.
• W1570750002 hasConcept C204232928 @default.
• W1570750002 hasConcept C2777760704 @default.
• W1570750002 hasConcept C2779013556 @default.
• W1570750002 hasConcept C2781197716 @default.
• W1570750002 hasConcept C38180746 @default.
• W1570750002 hasConcept C502942594 @default.
• W1570750002 hasConcept C50382708 @default.
• W1570750002 hasConcept C55493867 @default.
• W1570750002 hasConcept C71924100 @default.
• W1570750002 hasConcept C86803240 @default.
• W1570750002 hasConceptScore W1570750002C10515644 @default.
• W1570750002 hasConceptScore W1570750002C121608353 @default.
• W1570750002 hasConceptScore W1570750002C126322002 @default.
• W1570750002 hasConceptScore W1570750002C142724271 @default.
• W1570750002 hasConceptScore W1570750002C143998085 @default.
• W1570750002 hasConceptScore W1570750002C193270364 @default.
• W1570750002 hasConceptScore W1570750002C204232928 @default.
• W1570750002 hasConceptScore W1570750002C2777760704 @default.
• W1570750002 hasConceptScore W1570750002C2779013556 @default.
• W1570750002 hasConceptScore W1570750002C2781197716 @default.
• W1570750002 hasConceptScore W1570750002C38180746 @default.

• next