FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1570756084> ?p ?o ?g. }

• W1570756084 endingPage "524" @default.
• W1570756084 startingPage "516" @default.
• W1570756084 abstract "The B cell antigen receptor repertoire is highly diverse and constantly modified by clonal selection. High-throughput DNA sequencing (HTS) of the lymphocyte repertoire (Rep-Seq) represents a promising technology to explore such diversity ex-vivo and assist in the identification of antigen-specific antibodies based on molecular signatures of clonal selection. Therefore, integrative tools for repertoire reconstruction and analysis from antibody sequences are needed. We developed ImmunediveRity, a stand-alone pipeline primarily based in R programming for the integral analysis of B cell repertoire data generated by HTS. The pipeline integrates GNU software and in house scripts to perform quality filtering, sequencing noise correction and repertoire reconstruction based on V, D and J segment assignment, clonal origin and unique heavy chain identification. Post-analysis scripts generate a wealth of repertoire metrics that in conjunction with a rich graphical output facilitates sample comparison and repertoire mining. Its performance was tested with raw and curated human and mouse 454-Roche sequencing benchmarks providing good approximations of repertoire structure. Furthermore, ImmunediveRsity was used to mine the B cell repertoire of immunized mice with a model antigen, allowing the identification of previously validated antigen-specific antibodies, and revealing different and unexpected clonal diversity patterns in the post-immunization IgM and IgG compartments. Although ImmunediveRsity is similar to other recently developed tools, it offers significant advantages that facilitate repertoire analysis and repertoire mining. ImmunediveRsity is open source and free for academic purposes and it runs on 64 bit GNU/Linux and MacOS. Available at: https://bitbucket.org/ImmunediveRsity/immunediversity/" @default.
• W1570756084 created "2016-06-24" @default.
• W1570756084 creator A5005320356 @default.
• W1570756084 creator A5013187873 @default.
• W1570756084 creator A5020551704 @default.
• W1570756084 creator A5020947613 @default.
• W1570756084 creator A5024202655 @default.
• W1570756084 creator A5024285790 @default.
• W1570756084 creator A5030352999 @default.
• W1570756084 creator A5040788796 @default.
• W1570756084 creator A5075822017 @default.
• W1570756084 creator A5078370762 @default.
• W1570756084 creator A5081812114 @default.
• W1570756084 date "2015-04-15" @default.
• W1570756084 modified "2023-10-17" @default.
• W1570756084 title "Reconstructing and mining the B cell repertoire with ImmunediveRsity" @default.
• W1570756084 cites W135571511 @default.
• W1570756084 cites W1499793841 @default.
• W1570756084 cites W1561328814 @default.
• W1570756084 cites W1564554007 @default.
• W1570756084 cites W1643112662 @default.
• W1570756084 cites W1909049753 @default.
• W1570756084 cites W1940255384 @default.
• W1570756084 cites W1966949480 @default.
• W1570756084 cites W1967505760 @default.
• W1570756084 cites W1967867591 @default.
• W1570756084 cites W1969804838 @default.
• W1570756084 cites W1993928780 @default.
• W1570756084 cites W2000906546 @default.
• W1570756084 cites W2001550227 @default.
• W1570756084 cites W2006950109 @default.
• W1570756084 cites W2009694933 @default.
• W1570756084 cites W2012157496 @default.
• W1570756084 cites W2014113929 @default.
• W1570756084 cites W2015326011 @default.
• W1570756084 cites W2020450706 @default.
• W1570756084 cites W2022824615 @default.
• W1570756084 cites W2029525307 @default.
• W1570756084 cites W2038873256 @default.
• W1570756084 cites W2040580015 @default.
• W1570756084 cites W2042096299 @default.
• W1570756084 cites W2042786738 @default.
• W1570756084 cites W2054717882 @default.
• W1570756084 cites W2058013451 @default.
• W1570756084 cites W2064438534 @default.
• W1570756084 cites W2066827579 @default.
• W1570756084 cites W2068310820 @default.
• W1570756084 cites W2068470346 @default.
• W1570756084 cites W2084791457 @default.
• W1570756084 cites W2091142825 @default.
• W1570756084 cites W2102733876 @default.
• W1570756084 cites W2105273832 @default.
• W1570756084 cites W2122134741 @default.
• W1570756084 cites W2124351063 @default.
• W1570756084 cites W2128114769 @default.
• W1570756084 cites W2132375548 @default.
• W1570756084 cites W2132548846 @default.
• W1570756084 cites W2136877952 @default.
• W1570756084 cites W2138067488 @default.
• W1570756084 cites W2142081242 @default.
• W1570756084 cites W2152356263 @default.
• W1570756084 cites W2155111232 @default.
• W1570756084 cites W2158686006 @default.
• W1570756084 cites W2169979510 @default.
• W1570756084 cites W2578150941 @default.
• W1570756084 cites W4246504300 @default.
• W1570756084 doi "https://doi.org/10.1080/19420862.2015.1026502" @default.
• W1570756084 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4622655" @default.
• W1570756084 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25875140" @default.
• W1570756084 hasPublicationYear "2015" @default.
• W1570756084 type Work @default.
• W1570756084 sameAs 1570756084 @default.
• W1570756084 citedByCount "24" @default.
• W1570756084 countsByYear W15707560842015 @default.
• W1570756084 countsByYear W15707560842016 @default.
• W1570756084 countsByYear W15707560842017 @default.
• W1570756084 countsByYear W15707560842018 @default.
• W1570756084 countsByYear W15707560842019 @default.
• W1570756084 countsByYear W15707560842020 @default.
• W1570756084 countsByYear W15707560842021 @default.
• W1570756084 countsByYear W15707560842022 @default.
• W1570756084 countsByYear W15707560842023 @default.
• W1570756084 crossrefType "journal-article" @default.
• W1570756084 hasAuthorship W1570756084A5005320356 @default.
• W1570756084 hasAuthorship W1570756084A5013187873 @default.
• W1570756084 hasAuthorship W1570756084A5020551704 @default.
• W1570756084 hasAuthorship W1570756084A5020947613 @default.
• W1570756084 hasAuthorship W1570756084A5024202655 @default.
• W1570756084 hasAuthorship W1570756084A5024285790 @default.
• W1570756084 hasAuthorship W1570756084A5030352999 @default.
• W1570756084 hasAuthorship W1570756084A5040788796 @default.
• W1570756084 hasAuthorship W1570756084A5075822017 @default.
• W1570756084 hasAuthorship W1570756084A5078370762 @default.
• W1570756084 hasAuthorship W1570756084A5081812114 @default.
• W1570756084 hasBestOaLocation W15707560841 @default.
• W1570756084 hasConcept C116834253 @default.
• W1570756084 hasConcept C121332964 @default.
• W1570756084 hasConcept C147483822 @default.

• next