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• W1570763249 abstract "ABSTRACT TThe hepatotoxicity and nephrotoxicity of chlorpyrifos (CPF) and imidacloprid (IMC) insecticides were he hepatotoxicity and nephrotoxicity of chlorpyrifos (CPF) and imidacloprid (IMC) insecticides were eexperimentally studied in layer chickens, taking into account the patho-biochemical alterations. The LDxperimentally studied in layer chickens, taking into account the patho-biochemical alterations. The LD 5500 values values eestimated were 41 mg/kg bw and 104.1 mg/kg bw for CPF and IMC, respectively. The plasma cholineesterase stimated were 41 mg/kg bw and 104.1 mg/kg bw for CPF and IMC, respectively. The plasma cholineesterase eenzyme was severely inhibited in chickens given a single dose of CPF at a rate of 55 mg/kg bw via oral nzyme was severely inhibited in chickens given a single dose of CPF at a rate of 55 mg/kg bw via oral ggavage, while it remained unchanged in chickens given IMC at rate of 139 mg/kg bw via similar route. The avage, while it remained unchanged in chickens given IMC at rate of 139 mg/kg bw via similar route. The aactivities of liver function enzymes viz. AKP, ALT and AST were signictivities of liver function enzymes viz. AKP, ALT and AST were signifi cantly increased in chickens of CPF cantly increased in chickens of CPF aand IMC groups. Uric acid level was signind IMC groups. Uric acid level was signifi cantly increased and cholesterol level was only signicantly increased and cholesterol level was only signifi cantly reduced cantly reduced iin the plasma of chickens administrated CPF. Plasma glucose values in chickens given CPF as well as in n the plasma of chickens administrated CPF. Plasma glucose values in chickens given CPF as well as in cchickens given IMC were signihickens given IMC were signifi cantly increased at (P<0.01) and (P<0.05), respectively. Microscopically, liver cantly increased at (P<0.01) and (P<0.05), respectively. Microscopically, liver ttissue of CPF intoxicated chickens showed degeneration, coagulative necrosis and hemorrhages. The kidneys issue of CPF intoxicated chickens showed degeneration, coagulative necrosis and hemorrhages. The kidneys sshowed hemorrhages, vacuolar degeneration of tubular epithelial cells as well as focal coagulative necrosis. howed hemorrhages, vacuolar degeneration of tubular epithelial cells as well as focal coagulative necrosis. MMicroscopic lesions of a similar type were observed in chickens given IMC. The exposure to CPF and IMC icroscopic lesions of a similar type were observed in chickens given IMC. The exposure to CPF and IMC pproduced histopathological changes that could be correlated with changes in the biochemical proroduced histopathological changes that could be correlated with changes in the biochemical profi le of layer le of layer cchickens.hickens." @default.
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• W1570763249 date "2010-10-26" @default.
• W1570763249 modified "2023-09-23" @default.
• W1570763249 title "Patho-biochemical studies on hepatotoxicity and nephrotoxicity on exposure to chlorpyrifos and imidacloprid in layer chickens" @default.
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