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• W1570789552 abstract "Abstract : The purpose of this study is to determine the functional role of the putative oncogene BORIS in ovarian cancer. The proposed studies will use a newly developed mouse model system to assess the oncogenic potential of BORIS expression in the ovarian surface epithelium, alone and in combination with Rb and p53 knockout. In the past year we have accomplished a number of objectives: i) we have obtained IACUC, ACURO, and Biosafety approvals for the proposed studies, ii) we designed and constructed a new conditional overexpression construct (iZEG-CTCFL) to drive BORIS expression in mice, iii) we obtained double conditional knockout mice (Rb, p53) in FVB/N background and bred with FVB/N wild-type mice, obtained F1 mice and intercrossed to generate stocks of single Rbflox or p53flox mice. iv) we obtained founder BORIS-Tg mice and are currently crossing into the FVB/N strain to fully characterize the transgenic gene configuration, v) we conducted intrabursal Ad-Cre injections to generate cohorts of conditionally deleted Rb and p53 in mice, measured ovary/tumor volume over 300 days by MRI, and confirmed that double mutant mice have significantly enhanced ovary/tumor growth, and vi) Ms. March has learned how to isolate and culture OSE cells from mice and has begun to isolate and utilize these cultures to meet the study objectives." @default.
• W1570789552 created "2016-06-24" @default.
• W1570789552 creator A5006143467 @default.
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• W1570789552 date "2013-10-01" @default.
• W1570789552 modified "2023-09-23" @default.
• W1570789552 title "Functional Assessment of the Role of BORIS in Ovarian Cancer Using a Novel In Vivo Model System" @default.
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• W1570789552 doi "https://doi.org/10.21236/ada598204" @default.
• W1570789552 hasPublicationYear "2013" @default.
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