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- W1570794385 abstract "Glial cells are now recognised to be important modulators of the innate immune responsein the nervous system. While the focus to date has primarily been on astrocytes andSchwann cells, the immunomodulatory properties of a third class of macroglia, olfactoryensheathing cells (OECs), also warrant investigation. OECs reside in the primaryolfactory system and ensheath the olfactory nerves along their length from the nasalcavity to the olfactory bulbs in the central nervous system (CNS). Olfactory neurons areunique among neurons in providing uninterrupted conduits for neurotropic pathogens tospread from the external environment directly into the brain. There is continual turnoverof olfactory neurons throughout life and OECs phagocytose the axonal debris to facilitatenew axonal growth. Given that infected olfactory neurons undergo widespread apoptosis,it is likely that OECs contribute to the innate immune response to such infections. Thischapter will discuss recent data demonstrating that OECs are immunocompetent cells in amanner similar to astrocytes, and that this has significant implications for the use ofOECs in spinal cord transplantation therapies." @default.
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- W1570794385 date "2008-01-01" @default.
- W1570794385 modified "2023-09-26" @default.
- W1570794385 title "Glial modulation of the innate immune response: olfactory ensheathing cells join the melee?" @default.
- W1570794385 hasPublicationYear "2008" @default.
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