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- W1570830235 endingPage "26" @default.
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- W1570830235 abstract "Since its discovery in Caenorhabditis elegans in 1998, RNA interference (RNAi) has become an invaluable tool for functional genetic studies. Sequencing of the human genome has identified all potentially expressed genes, and RNAi trigger molecules (siRNA or shRNA) can be designed to silence any gene in the entire genome. When the silencing of a particular gene is affecting a given phenotype, new discoveries can be made about gene function. This principle has been exploited for large-scale (high-throughput) functional screens in which genes are systematically silenced and the effect on a given phenotype is determined by using a suitable assay. In this chapter, an overview will be provided of RNAi screening technology, including the design of trigger molecules, approaches to RNAi screening, methods to analyze screening results, and the applications of RNAi screens. Attention will be focused on the challenges and solutions to designing and analyzing results from human RNAi screens.Keywords:RNA interference (RNAi);RNA-induced silencing complex (RISC);small (or short) interfering RNAs (siRNAs);short hairpin RNAs (shRNAs);RNAi screen;arrayed screen;pooled screen" @default.
- W1570830235 created "2016-06-24" @default.
- W1570830235 creator A5028345411 @default.
- W1570830235 creator A5081217777 @default.
- W1570830235 date "2013-10-02" @default.
- W1570830235 modified "2023-09-24" @default.
- W1570830235 title "RNAi Screening and Assays" @default.
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