FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1570851270> ?p ?o ?g. }

• W1570851270 endingPage "14685" @default.
• W1570851270 startingPage "14681" @default.
• W1570851270 abstract "Down-regulation of atrial natriuretic peptide (ANP) receptors was investigated using a cultured bovine pulmonary artery endothelial (CPAE) cell line. Endothelial cells have been shown to possess two subtypes of ANP receptors, a guanylate cyclase-coupled receptor (B-receptor) and a clearance receptor (C-receptor). The treatment with APIII, rat ANP (103-126), at concentrations of 10(-8) to 10(-6) M for 24 h, resulted in a significantly (p less than 0.01) greater decrease in maximum 125I-APIII binding to CPAE cells than the identical concentration of API, rat ANP (103-123). APIII at concentrations of 10(-8) to 10(-6) M stimulated cyclic GMP (cGMP) production 3.3-17.5-fold greater than similar concentrations of API. From these findings, we hypothesized that cGMP produced following ANP binding to the B-receptor participates in ANP receptor regulation. M&B 22948, a selective inhibitor of cGMP-specific phosphodiesterase, significantly (p less than 0.01) potentiated the effect of both API and APIII on 125I-APIII binding, while M&B 22948 itself had no significant effect on 125I-APIII binding. Treatment of the cells with 1 mM 8-bromo-cGMP also significantly (p less than 0.01) decreased 125I-APIII binding to the cells, and a potentiation of this effect was observed by M&B 22948. Scatchard analysis of binding data from 8-bromo-cGMP-treated cells showed a significant decrease in Bmax (1.79 +/- 0.15 to 1.20 +/- 0.07 fmol/mg protein, p less than 0.05) without a significant change in Kd. Affinity cross-linking of 125I-APIII to 8-bromo-cGMP-treated cells showed a decrease in the labeling of 60- and 70-kDa bands corresponding to the C-receptor. In addition, the APIII-stimulated cGMP response remained unchanged in the 8-bromo-cGMP-treated cells, indicating that the B-receptor was not down-regulated. We conclude that cGMP regulates ANP-binding sites on the endothelial cell and that the evidence indicates that the C-receptor may preferentially be down-regulated by cGMP in CPAE cells." @default.
• W1570851270 created "2016-06-24" @default.
• W1570851270 creator A5001446657 @default.
• W1570851270 creator A5007263582 @default.
• W1570851270 creator A5090599179 @default.
• W1570851270 date "1991-08-01" @default.
• W1570851270 modified "2023-10-17" @default.
• W1570851270 title "Cyclic GMP down-regulates atrial natriuretic peptide receptors on cultured vascular endothelial cells" @default.
• W1570851270 cites W1511221661 @default.
• W1570851270 cites W1528933165 @default.
• W1570851270 cites W1553668020 @default.
• W1570851270 cites W1566921440 @default.
• W1570851270 cites W1579015292 @default.
• W1570851270 cites W1593231964 @default.
• W1570851270 cites W1775749144 @default.
• W1570851270 cites W1912249044 @default.
• W1570851270 cites W1969575232 @default.
• W1570851270 cites W1978038902 @default.
• W1570851270 cites W1984014988 @default.
• W1570851270 cites W1993183122 @default.
• W1570851270 cites W1996285376 @default.
• W1570851270 cites W2004723372 @default.
• W1570851270 cites W2024494699 @default.
• W1570851270 cites W2034376730 @default.
• W1570851270 cites W2043813981 @default.
• W1570851270 cites W2047184705 @default.
• W1570851270 cites W2054649519 @default.
• W1570851270 cites W2055646611 @default.
• W1570851270 cites W2075841417 @default.
• W1570851270 cites W2080512195 @default.
• W1570851270 cites W2080580789 @default.
• W1570851270 cites W2080920568 @default.
• W1570851270 cites W2082370756 @default.
• W1570851270 cites W2085808713 @default.
• W1570851270 cites W2105046056 @default.
• W1570851270 cites W2144008453 @default.
• W1570851270 cites W390461 @default.
• W1570851270 doi "https://doi.org/10.1016/s0021-9258(18)98739-9" @default.
• W1570851270 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1650366" @default.
• W1570851270 hasPublicationYear "1991" @default.
• W1570851270 type Work @default.
• W1570851270 sameAs 1570851270 @default.
• W1570851270 citedByCount "52" @default.
• W1570851270 countsByYear W15708512702018 @default.
• W1570851270 countsByYear W15708512702020 @default.
• W1570851270 countsByYear W15708512702023 @default.
• W1570851270 crossrefType "journal-article" @default.
• W1570851270 hasAuthorship W1570851270A5001446657 @default.
• W1570851270 hasAuthorship W1570851270A5007263582 @default.
• W1570851270 hasAuthorship W1570851270A5090599179 @default.
• W1570851270 hasBestOaLocation W15708512701 @default.
• W1570851270 hasConcept C126322002 @default.
• W1570851270 hasConcept C134018914 @default.
• W1570851270 hasConcept C170493617 @default.
• W1570851270 hasConcept C185592680 @default.
• W1570851270 hasConcept C2775915353 @default.
• W1570851270 hasConcept C2778069365 @default.
• W1570851270 hasConcept C2778198053 @default.
• W1570851270 hasConcept C2779281246 @default.
• W1570851270 hasConcept C3020139451 @default.
• W1570851270 hasConcept C3156946 @default.
• W1570851270 hasConcept C519581460 @default.
• W1570851270 hasConcept C55493867 @default.
• W1570851270 hasConcept C71924100 @default.
• W1570851270 hasConcept C86803240 @default.
• W1570851270 hasConcept C8741621 @default.
• W1570851270 hasConcept C95444343 @default.
• W1570851270 hasConceptScore W1570851270C126322002 @default.
• W1570851270 hasConceptScore W1570851270C134018914 @default.
• W1570851270 hasConceptScore W1570851270C170493617 @default.
• W1570851270 hasConceptScore W1570851270C185592680 @default.
• W1570851270 hasConceptScore W1570851270C2775915353 @default.
• W1570851270 hasConceptScore W1570851270C2778069365 @default.
• W1570851270 hasConceptScore W1570851270C2778198053 @default.
• W1570851270 hasConceptScore W1570851270C2779281246 @default.
• W1570851270 hasConceptScore W1570851270C3020139451 @default.
• W1570851270 hasConceptScore W1570851270C3156946 @default.
• W1570851270 hasConceptScore W1570851270C519581460 @default.
• W1570851270 hasConceptScore W1570851270C55493867 @default.
• W1570851270 hasConceptScore W1570851270C71924100 @default.
• W1570851270 hasConceptScore W1570851270C86803240 @default.
• W1570851270 hasConceptScore W1570851270C8741621 @default.
• W1570851270 hasConceptScore W1570851270C95444343 @default.
• W1570851270 hasIssue "22" @default.
• W1570851270 hasLocation W15708512701 @default.
• W1570851270 hasOpenAccess W1570851270 @default.
• W1570851270 hasPrimaryLocation W15708512701 @default.
• W1570851270 hasRelatedWork W1968130104 @default.
• W1570851270 hasRelatedWork W1972033663 @default.
• W1570851270 hasRelatedWork W1998443384 @default.
• W1570851270 hasRelatedWork W2026039325 @default.
• W1570851270 hasRelatedWork W2030994453 @default.
• W1570851270 hasRelatedWork W2147480685 @default.
• W1570851270 hasRelatedWork W2327185741 @default.
• W1570851270 hasRelatedWork W3140667117 @default.
• W1570851270 hasRelatedWork W4235866023 @default.
• W1570851270 hasRelatedWork W4251712044 @default.
• W1570851270 hasVolume "266" @default.

• next