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• W1570880516 abstract "Summary electronic version • IEvery organism experiences the effects of stress in its day to day life.Stress can be defined as any disturbance of the organism’s homeostasis.The inter-nalor external stimulus that causes stress is called the stressor. Usually, the organ-ismis well equipped to adapt to the stress. It has the mechanisms, generallyreferred to as the stress response, to restore its disturbed homeostasis. However,severe and chronic stress may exceed the ability to adapt and this may then leadto suppression of growth, the immune response or the reproductive perform-ance.In fish, as in higher vertebrates, stress adaptation has been shown to berelated to an activation of the hypothalamic-pituitary-interrenal (HPI) axis. Inteleost fish, cortisol is the main glucocorticoid produced by the interrenalsunder influence of stress. Cortisol plays a key role in the restoration of home-ostasisand is frequently indicated to be the major factor mediating the suppres-siveeffect of stress on the reproductive performance.This thesis addresses the effect of stress adaptation on the pubertal development.Puberty is the developmental process by which the animal acquires the capaci-tyto reproduce. In males, the period of pubertal development may be defined asthe time span that starts with the beginning of spermatogonial multiplicationuntil the appearance of the first flagellated spermatozoa. The onset and regula-tionof puberty is determined by functional development of the brain-pituitary-gonad(BPG) axis. Stress effects have been reported to affect all levels of theBPG-axis. However, the precise mechanisms via which the stress response has itsadverse effects on reproduction are still unknown.The present study is an attempt to find more answers to solve thisintriguing question. Firstly, we investigated the effects of repeated temperaturestress on the pubertal development (Chapter 2). Since cortisol has been shownto play a key role in the homeostatic adaptation during or after stress, wefocussed in chapter 3 on the effects of cortisol on the pubertal development. Inthe same chapter we also paid attention to the question at which level the BPG-axisis affected by cortisol. Since our results indicate that all levels of the BPG-axiswere affected by cortisol, we studied the cortisol effects on the pituitary and?the testis in more detail (chapter 4 and in chapter 5) and tried to answer thequestion whether cortisol has its effects, directly or indirectly on the differentcomponents of the BPG-axis. Based on these studies we hypothesized that thecortisol-induced suppression of pubertal development is mediated by effects onthe androgen production. In the following chapter, chapter 6, we thereforeintensified our research on the testis, focussing on the steroid synthesis. Finally,in chapter 7, we investigated the role of the androgens, which possibly play a keyrole in the cortisol-induced suppression of pubertal development, by combinedcortisol treatment and steroid replacement therapy." @default.
• W1570880516 created "2016-06-24" @default.
• W1570880516 creator A5017761068 @default.
• W1570880516 date "2001-04-23" @default.
• W1570880516 modified "2023-09-24" @default.
• W1570880516 title "Stress response and pubertal development in the male common carp, Cyprinus carpio L." @default.
• W1570880516 hasPublicationYear "2001" @default.
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