FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1570888300> ?p ?o ?g. }

• W1570888300 endingPage "40" @default.
• W1570888300 startingPage "35" @default.
• W1570888300 abstract "Abstract Adoptive transfer of proteolipid protein 139–151-specific T cell lines was used to examine the role of androgens in regulating T cell cytokine secretion and the severity of experimental autoimmune encephalomyelitis (EAE) in the SJL mouse. In this study, we found that T cells from female mice transferred more severe EAE than T cells from male mice and that gender differences in clinical disease were due, at least in part, to differences in donor T cell cytokine secretion. T cell lines were selected from proteolipid protein 139–151-immunized female SJL mice in the presence or absence of exogenous androgens. Androgen-selected T cell lines secreted less IFN-γ and more IL-10 than untreated cell lines. Clinical disease induced by the adoptive transfer of androgen-selected T cell lines was less severe than disease induced with untreated T cell lines. Furthermore, androgen treatment of naive TCR transgenic T cells, during their first encounter with Ag, resulted in a shift in the balance of Th1/Th2 cytokines. This phenotype was maintained during subsequent stimulations in the absence of androgen. These results suggest that androgen present in the lymphoid microenvironment during the induction of an immune response can alter the development of effector T cells and may play an important role in governing gender differences in the immune response and susceptibility to autoimmune disorders." @default.
• W1570888300 created "2016-06-24" @default.
• W1570888300 creator A5004052621 @default.
• W1570888300 creator A5032373525 @default.
• W1570888300 creator A5040206785 @default.
• W1570888300 creator A5087867695 @default.
• W1570888300 date "1999-01-01" @default.
• W1570888300 modified "2023-10-09" @default.
• W1570888300 title "Androgens Alter the Cytokine Profile and Reduce Encephalitogenicity of Myelin-Reactive T Cells" @default.
• W1570888300 cites W1020666978 @default.
• W1570888300 cites W1215373674 @default.
• W1570888300 cites W1519441922 @default.
• W1570888300 cites W1589679215 @default.
• W1570888300 cites W1605865008 @default.
• W1570888300 cites W1651151907 @default.
• W1570888300 cites W1914553247 @default.
• W1570888300 cites W1968357632 @default.
• W1570888300 cites W1974439206 @default.
• W1570888300 cites W1983895762 @default.
• W1570888300 cites W1986313484 @default.
• W1570888300 cites W1988109949 @default.
• W1570888300 cites W1989338168 @default.
• W1570888300 cites W1989379400 @default.
• W1570888300 cites W1991158043 @default.
• W1570888300 cites W1991653799 @default.
• W1570888300 cites W1992985178 @default.
• W1570888300 cites W2008269957 @default.
• W1570888300 cites W2010426863 @default.
• W1570888300 cites W2025591283 @default.
• W1570888300 cites W2029146247 @default.
• W1570888300 cites W2037061225 @default.
• W1570888300 cites W2040838085 @default.
• W1570888300 cites W2046123379 @default.
• W1570888300 cites W2049436228 @default.
• W1570888300 cites W2051586652 @default.
• W1570888300 cites W2055485094 @default.
• W1570888300 cites W2058561523 @default.
• W1570888300 cites W2059714334 @default.
• W1570888300 cites W2060718925 @default.
• W1570888300 cites W2062794300 @default.
• W1570888300 cites W2070793464 @default.
• W1570888300 cites W2074788705 @default.
• W1570888300 cites W2088561119 @default.
• W1570888300 cites W2106135511 @default.
• W1570888300 cites W2107621267 @default.
• W1570888300 cites W2108617074 @default.
• W1570888300 cites W2124116262 @default.
• W1570888300 cites W2160344320 @default.
• W1570888300 cites W2161154771 @default.
• W1570888300 cites W2198155930 @default.
• W1570888300 cites W4294216491 @default.
• W1570888300 doi "https://doi.org/10.4049/jimmunol.162.1.35" @default.
• W1570888300 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9886367" @default.
• W1570888300 hasPublicationYear "1999" @default.
• W1570888300 type Work @default.
• W1570888300 sameAs 1570888300 @default.
• W1570888300 citedByCount "188" @default.
• W1570888300 countsByYear W15708883002012 @default.
• W1570888300 countsByYear W15708883002013 @default.
• W1570888300 countsByYear W15708883002014 @default.
• W1570888300 countsByYear W15708883002015 @default.
• W1570888300 countsByYear W15708883002016 @default.
• W1570888300 countsByYear W15708883002017 @default.
• W1570888300 countsByYear W15708883002018 @default.
• W1570888300 countsByYear W15708883002019 @default.
• W1570888300 countsByYear W15708883002020 @default.
• W1570888300 countsByYear W15708883002021 @default.
• W1570888300 countsByYear W15708883002022 @default.
• W1570888300 countsByYear W15708883002023 @default.
• W1570888300 crossrefType "journal-article" @default.
• W1570888300 hasAuthorship W1570888300A5004052621 @default.
• W1570888300 hasAuthorship W1570888300A5032373525 @default.
• W1570888300 hasAuthorship W1570888300A5040206785 @default.
• W1570888300 hasAuthorship W1570888300A5087867695 @default.
• W1570888300 hasBestOaLocation W15708883001 @default.
• W1570888300 hasConcept C126322002 @default.
• W1570888300 hasConcept C134018914 @default.
• W1570888300 hasConcept C154317977 @default.
• W1570888300 hasConcept C202751555 @default.
• W1570888300 hasConcept C203014093 @default.
• W1570888300 hasConcept C2776090121 @default.
• W1570888300 hasConcept C2777426553 @default.
• W1570888300 hasConcept C2777911890 @default.
• W1570888300 hasConcept C2778486448 @default.
• W1570888300 hasConcept C2778609137 @default.
• W1570888300 hasConcept C2778690821 @default.
• W1570888300 hasConcept C2780876595 @default.
• W1570888300 hasConcept C529278444 @default.
• W1570888300 hasConcept C55493867 @default.
• W1570888300 hasConcept C71315377 @default.
• W1570888300 hasConcept C71924100 @default.
• W1570888300 hasConcept C86803240 @default.
• W1570888300 hasConcept C8891405 @default.
• W1570888300 hasConcept C90375314 @default.
• W1570888300 hasConceptScore W1570888300C126322002 @default.
• W1570888300 hasConceptScore W1570888300C134018914 @default.
• W1570888300 hasConceptScore W1570888300C154317977 @default.
• W1570888300 hasConceptScore W1570888300C202751555 @default.

• next