Matches in SemOpenAlex for { <https://semopenalex.org/work/W1570961631> ?p ?o ?g. }
- W1570961631 endingPage "422" @default.
- W1570961631 startingPage "408" @default.
- W1570961631 abstract "The ventral tegmental area (VTA) contains dopamine (DA) and gamma-aminobutyric acid (GABA) neurons involved in motivation and behavioral state. These phenomena are also influenced by circadian factors. The goal of our studies was to examine the impulse activity of neurochemically identified VTA neurons during dark (active) vs light (rest) phases of the circadian cycle. Using extracellular single-unit recordings with juxtacellular labeling in anesthetized rats, we found multiple neuronal subpopulations including 'novel neurons' that selectively fired during the dark phase. These novel neurons were electrophysiologically categorized into two groups, 'novel wide-spike' and 'novel thin-spike' neurons. Characterization of novel wide-spike neurons found they were consistently non-dopaminergic and non-GABAergic [tyrosine hydroxylase (TH)(-), glutamic acid decarboxylase (GAD)(-)]. However, they were inhibited by the D2 agonist quinpirole, an effect that could be reversed by the D2 antagonist eticlopride. Physiologically, they were fast firing (mean = 18.9 +/- 1.2 spikes/s), low bursting neurons (median = 6.2 +/- 3.0% of spikes in bursts) with spike durations > or = 2.0 ms, but slightly shorter than TH(+) neurons. They were also consistently non-responsive to footpad stimulation. The novel thin-spike neurons were neurochemically heterogeneous, and were located more ventrally than thin-spike neurons found during the light phase. These findings reveal previously unknown populations of VTA neurons whose activities are sensitive to diurnal phase, and whose functions may be in the temporal regulation of arousal and motivational processes." @default.
- W1570961631 created "2016-06-24" @default.
- W1570961631 creator A5023948132 @default.
- W1570961631 creator A5030113568 @default.
- W1570961631 creator A5036547376 @default.
- W1570961631 date "2008-01-18" @default.
- W1570961631 modified "2023-09-25" @default.
- W1570961631 title "Novel neurons in ventral tegmental area fire selectively during the active phase of the diurnal cycle" @default.
- W1570961631 cites W1487132131 @default.
- W1570961631 cites W1538619854 @default.
- W1570961631 cites W1597278618 @default.
- W1570961631 cites W1652173018 @default.
- W1570961631 cites W1764026126 @default.
- W1570961631 cites W1831515958 @default.
- W1570961631 cites W1840984304 @default.
- W1570961631 cites W1949404224 @default.
- W1570961631 cites W1966777631 @default.
- W1570961631 cites W1969414607 @default.
- W1570961631 cites W1969827231 @default.
- W1570961631 cites W1973372728 @default.
- W1570961631 cites W1974400595 @default.
- W1570961631 cites W1976368638 @default.
- W1570961631 cites W1979194704 @default.
- W1570961631 cites W1979197997 @default.
- W1570961631 cites W1979332775 @default.
- W1570961631 cites W1981864483 @default.
- W1570961631 cites W1981896177 @default.
- W1570961631 cites W1983383694 @default.
- W1570961631 cites W1983985508 @default.
- W1570961631 cites W1985694024 @default.
- W1570961631 cites W1989176150 @default.
- W1570961631 cites W1992341044 @default.
- W1570961631 cites W1997065612 @default.
- W1570961631 cites W1998152406 @default.
- W1570961631 cites W1998352623 @default.
- W1570961631 cites W1999871997 @default.
- W1570961631 cites W2004156074 @default.
- W1570961631 cites W2011454209 @default.
- W1570961631 cites W2018760402 @default.
- W1570961631 cites W2018981804 @default.
- W1570961631 cites W2022125333 @default.
- W1570961631 cites W2023190048 @default.
- W1570961631 cites W2023504580 @default.
- W1570961631 cites W2028851681 @default.
- W1570961631 cites W2037060024 @default.
- W1570961631 cites W2038825302 @default.
- W1570961631 cites W2041800086 @default.
- W1570961631 cites W2045857070 @default.
- W1570961631 cites W2047843802 @default.
- W1570961631 cites W2048397695 @default.
- W1570961631 cites W2048752288 @default.
- W1570961631 cites W2052001699 @default.
- W1570961631 cites W2054003218 @default.
- W1570961631 cites W2054719361 @default.
- W1570961631 cites W2055646762 @default.
- W1570961631 cites W2056336718 @default.
- W1570961631 cites W2056436878 @default.
- W1570961631 cites W2058578514 @default.
- W1570961631 cites W2059702479 @default.
- W1570961631 cites W2060923069 @default.
- W1570961631 cites W2061350749 @default.
- W1570961631 cites W2070530252 @default.
- W1570961631 cites W2071389360 @default.
- W1570961631 cites W2075831689 @default.
- W1570961631 cites W2086628930 @default.
- W1570961631 cites W2093024075 @default.
- W1570961631 cites W2103820482 @default.
- W1570961631 cites W2113895006 @default.
- W1570961631 cites W2117922300 @default.
- W1570961631 cites W2120574801 @default.
- W1570961631 cites W2123022860 @default.
- W1570961631 cites W2128211763 @default.
- W1570961631 cites W2138127541 @default.
- W1570961631 cites W2138199391 @default.
- W1570961631 cites W2140395780 @default.
- W1570961631 cites W2150299732 @default.
- W1570961631 cites W2150465961 @default.
- W1570961631 cites W2159702118 @default.
- W1570961631 cites W2169938627 @default.
- W1570961631 cites W2315916735 @default.
- W1570961631 doi "https://doi.org/10.1111/j.1460-9568.2007.05985.x" @default.
- W1570961631 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18215237" @default.
- W1570961631 hasPublicationYear "2008" @default.
- W1570961631 type Work @default.
- W1570961631 sameAs 1570961631 @default.
- W1570961631 citedByCount "72" @default.
- W1570961631 countsByYear W15709616312012 @default.
- W1570961631 countsByYear W15709616312013 @default.
- W1570961631 countsByYear W15709616312014 @default.
- W1570961631 countsByYear W15709616312015 @default.
- W1570961631 countsByYear W15709616312016 @default.
- W1570961631 countsByYear W15709616312017 @default.
- W1570961631 countsByYear W15709616312018 @default.
- W1570961631 countsByYear W15709616312019 @default.
- W1570961631 countsByYear W15709616312020 @default.
- W1570961631 countsByYear W15709616312022 @default.
- W1570961631 crossrefType "journal-article" @default.
- W1570961631 hasAuthorship W1570961631A5023948132 @default.