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- W1570967044 abstract "Abstract An imminent need exists to design improved adjuvants and vaccines to control emerging and re-emerging diseases. An ideal vaccine will mimic the way in which a naturally occurring infection induces a robust immune response yet avoids the undesirable effects of disease. To accomplish this, new adjuvants must engage pattern recognition receptors on antigen presenting cells (APCs). In this work, we employ a novel strategy to enhance the adjuvanticity of polyanhydride nanoparticles (NP) composed of 1,8-bis(p-carboxyphenoxy)-3,6-dioxaoctane (CPTEG) and 1,6-bis(p-carboxyphenoxy) hexane (CPH) by decorating their surface with the pathogen associated molecular pattern di-mannose (diM) to confer “pathogen-like” properties. Co-incubation of diM-NP with APCs elicited significant increases in surface expression of antigen presentation and co-stimulatory molecules and secretion of proinflammatory cytokines. An 800% increase in uptake of diM-NP was also observed. Furthermore, the mechanism of NP uptake was actin mediated and clathrin dependent, as is the case for many bacterial pathogens. Together, our data show that diM-NP possessed similar patterns of intracellular fate, persistence and APC activation as did live, pathogenic Y. pestis and E. coli. The innovative combination of polyanhydride NPs and di-mannose modification provides mechanistic insight into the properties required for next-generation adjuvants to safely mimic the immune stimulating activities of bacterial pathogens." @default.
- W1570967044 created "2016-06-24" @default.
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- W1570967044 date "2012-05-01" @default.
- W1570967044 modified "2023-09-26" @default.
- W1570967044 title "Carbohydrate modification of novel polyanhydride nanoparticle adjuvants to promote pathogen-mimicking characteristics (166.5)" @default.
- W1570967044 doi "https://doi.org/10.4049/jimmunol.188.supp.166.5" @default.
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