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- W1570976496 abstract "Abstract Certain antibodies may attach to the surface of macrophages by means of a receptor site located on the Fc portion of the molecule. This property, which is known as cytophilic binding, may be used as the basis of an assay procedure for the detection of antibody. If the antigen is conjugated to the surface of an erythrocyte, the cytophilic antibody can then act as a bridge linking the erythrocyte to the macrophage. This leads to the formation of rosettes which are readily visible in either stained or unstained preparations. When the reaction is performed with serial dilutions of antibody, reproducible end-points are obtained at low antibody concentrations. The sensitivity of the method compares favorably with that of several other immunologic procedures examined. Thus, cytophilic binding may be of use either for detecting antibody activity in an unknown preparation, or for the further characterization of a known antiserum in terms of its various Fc-dependent properties." @default.
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- W1570976496 date "1971-11-01" @default.
- W1570976496 modified "2023-10-17" @default.
- W1570976496 title "Cytophilic Binding of Antigen-Conjugated Erythrocytes: A Sensitive Assay" @default.
- W1570976496 doi "https://doi.org/10.4049/jimmunol.107.5.1394" @default.
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