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• W1570982932 abstract "1. Using a multiple-site optical recording method with a 100-element photodiode array and a voltage-sensitive merocyanine-rhodanine dye, we have been able to monitor, for the first time, spontaneous electrical activity in pre-fused cardiac primordia in the 6- and 7-somite chick embryos. 2. To study the regional development of spontaneous electrical activity in the early embryonic pre-contractile chick heart at the later 7-9-somite stages, we have also recorded optically action potentials simultaneously from the entire heart, and constructed maps of the early development of electrical activity. 3. The data show that during the 6-9-somite stages, the size of the active area gradually increases, and that the development of electrical activity was spatially non-uniform: two peaks of activity were found in the right and left sides of the cono-ventricular region at the 7-8-somite stages. As development proceeded to the 9-somite stage, several peak areas of activity appeared. 4. The results are discussed in relation to the spatial pattern of proliferation of electrically active cells in the early phases of cardiogenesis." @default.
• W1570982932 created "2016-06-24" @default.
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• W1570982932 date "1987-02-01" @default.
• W1570982932 modified "2023-10-15" @default.
• W1570982932 title "Mapping of early development of electrical activity in the embryonic chick heart using multiple-site optical recording." @default.
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• W1570982932 doi "https://doi.org/10.1113/jphysiol.1987.sp016437" @default.
• W1570982932 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1183098" @default.
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