FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1571009547> ?p ?o ?g. }

• W1571009547 abstract "We recently characterized a decapeptide sequence (residues 367-376) that is important for the membrane association of the activated alpha subunit of Gs. We report here that when this sequence is replaced by the cognate sequence of Gi1 alpha subunit, the chimeric protein (Gsis alpha) still interacts with the membrane but cannot be activated, regardless of the mode of activation. Construction of various chimeras demonstrates that the single replacement of valine 367 by threonine, the cognate residue of Gi1 alpha subunit, fully reproduces the loss of activation. Analysis of nucleotide interaction reveals that the mutant V367T Gs alpha protein poorly binds GDP or GTP. On the other hand, the conservative change of valine to isoleucine does not alter activation. Interestingly, members of the Gs and G12 classes have a valine and an isoleucine, respectively, at this position, whereas members of the Gi or Gq class contain a threonine residue. The evolutionary relationship between the different classes suggests that the presence of a hydrophobic or a hydrophilic residue is not fortuitous in these alpha subunits and might provide distinctive structural and/or functional properties." @default.
• W1571009547 created "2016-06-24" @default.
• W1571009547 creator A5021932811 @default.
• W1571009547 creator A5038543228 @default.
• W1571009547 creator A5045863654 @default.
• W1571009547 creator A5056803967 @default.
• W1571009547 creator A5061658943 @default.
• W1571009547 date "1994-08-01" @default.
• W1571009547 modified "2023-10-03" @default.
• W1571009547 title "Mutation of valine residue unique to alpha subunit of Gs abolishes activation." @default.
• W1571009547 cites W1447248578 @default.
• W1571009547 cites W1482295894 @default.
• W1571009547 cites W1499138436 @default.
• W1571009547 cites W1567363045 @default.
• W1571009547 cites W182982796 @default.
• W1571009547 cites W1942777601 @default.
• W1571009547 cites W1972760976 @default.
• W1571009547 cites W1975651701 @default.
• W1571009547 cites W1977598234 @default.
• W1571009547 cites W1990401009 @default.
• W1571009547 cites W2005189737 @default.
• W1571009547 cites W2036766910 @default.
• W1571009547 cites W2039094079 @default.
• W1571009547 cites W2052372063 @default.
• W1571009547 cites W2055748995 @default.
• W1571009547 cites W2060913542 @default.
• W1571009547 cites W2100837269 @default.
• W1571009547 cites W2165340830 @default.
• W1571009547 cites W2169503005 @default.
• W1571009547 doi "https://doi.org/10.1016/s0021-9258(17)31906-3" @default.
• W1571009547 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8063706" @default.
• W1571009547 hasPublicationYear "1994" @default.
• W1571009547 type Work @default.
• W1571009547 sameAs 1571009547 @default.
• W1571009547 citedByCount "2" @default.
• W1571009547 crossrefType "journal-article" @default.
• W1571009547 hasAuthorship W1571009547A5021932811 @default.
• W1571009547 hasAuthorship W1571009547A5038543228 @default.
• W1571009547 hasAuthorship W1571009547A5045863654 @default.
• W1571009547 hasAuthorship W1571009547A5056803967 @default.
• W1571009547 hasAuthorship W1571009547A5061658943 @default.
• W1571009547 hasBestOaLocation W15710095471 @default.
• W1571009547 hasConcept C104292427 @default.
• W1571009547 hasConcept C104317684 @default.
• W1571009547 hasConcept C118716 @default.
• W1571009547 hasConcept C11960822 @default.
• W1571009547 hasConcept C164083038 @default.
• W1571009547 hasConcept C167625842 @default.
• W1571009547 hasConcept C170493617 @default.
• W1571009547 hasConcept C181199279 @default.
• W1571009547 hasConcept C185592680 @default.
• W1571009547 hasConcept C2775880066 @default.
• W1571009547 hasConcept C2776414213 @default.
• W1571009547 hasConcept C2776580952 @default.
• W1571009547 hasConcept C2777305461 @default.
• W1571009547 hasConcept C2777573094 @default.
• W1571009547 hasConcept C2781338088 @default.
• W1571009547 hasConcept C515207424 @default.
• W1571009547 hasConcept C55493867 @default.
• W1571009547 hasConcept C71240020 @default.
• W1571009547 hasConcept C80631254 @default.
• W1571009547 hasConcept C83730767 @default.
• W1571009547 hasConcept C86803240 @default.
• W1571009547 hasConceptScore W1571009547C104292427 @default.
• W1571009547 hasConceptScore W1571009547C104317684 @default.
• W1571009547 hasConceptScore W1571009547C118716 @default.
• W1571009547 hasConceptScore W1571009547C11960822 @default.
• W1571009547 hasConceptScore W1571009547C164083038 @default.
• W1571009547 hasConceptScore W1571009547C167625842 @default.
• W1571009547 hasConceptScore W1571009547C170493617 @default.
• W1571009547 hasConceptScore W1571009547C181199279 @default.
• W1571009547 hasConceptScore W1571009547C185592680 @default.
• W1571009547 hasConceptScore W1571009547C2775880066 @default.
• W1571009547 hasConceptScore W1571009547C2776414213 @default.
• W1571009547 hasConceptScore W1571009547C2776580952 @default.
• W1571009547 hasConceptScore W1571009547C2777305461 @default.
• W1571009547 hasConceptScore W1571009547C2777573094 @default.
• W1571009547 hasConceptScore W1571009547C2781338088 @default.
• W1571009547 hasConceptScore W1571009547C515207424 @default.
• W1571009547 hasConceptScore W1571009547C55493867 @default.
• W1571009547 hasConceptScore W1571009547C71240020 @default.
• W1571009547 hasConceptScore W1571009547C80631254 @default.
• W1571009547 hasConceptScore W1571009547C83730767 @default.
• W1571009547 hasConceptScore W1571009547C86803240 @default.
• W1571009547 hasLocation W15710095471 @default.
• W1571009547 hasOpenAccess W1571009547 @default.
• W1571009547 hasPrimaryLocation W15710095471 @default.
• W1571009547 hasRelatedWork W1480582415 @default.
• W1571009547 hasRelatedWork W1483752684 @default.
• W1571009547 hasRelatedWork W1489461884 @default.
• W1571009547 hasRelatedWork W1538215265 @default.
• W1571009547 hasRelatedWork W1548346663 @default.
• W1571009547 hasRelatedWork W1549608820 @default.
• W1571009547 hasRelatedWork W1569652852 @default.
• W1571009547 hasRelatedWork W1586780384 @default.
• W1571009547 hasRelatedWork W1688381890 @default.
• W1571009547 hasRelatedWork W1864293601 @default.
• W1571009547 hasRelatedWork W1974458565 @default.
• W1571009547 hasRelatedWork W1976540841 @default.
• W1571009547 hasRelatedWork W1982251147 @default.

• next