Matches in SemOpenAlex for { <https://semopenalex.org/work/W1571197042> ?p ?o ?g. }
- W1571197042 endingPage "516" @default.
- W1571197042 startingPage "503" @default.
- W1571197042 abstract "This chapter reviews human surrogate models of neuropathic pain that focus on the mechanisms of symptom generation. A vast array of human surrogate models exists for ongoing symptoms, for positive sensory symptoms, and for sensory loss. The chapter discusses that by design, human surrogate models of neuropathic pain involve a reversible modulation of the properties of the nociceptive system such as its acute plasticity (phase 2). They usually do not create a long-lasting and potentially irreversible modification (phase 3). The denervation and ectopic activity of phase 3 can be modeled to a certain extent by transient nerve compression–ischemia and by topical capsaicin. By being models for phase 2 mechanisms, however, most human surrogate models mimic sensory symptoms that may occur in both neuropathic and nociceptive pain. The chapter reviews that each sensory finding is compatible with several neurobiological and neuropharmacological mechanisms, because of convergence in the generation of clinical manifestations. Thorough characterization of human surrogate models may in the future lead to a refinement of the proposed grouping scheme. Already at the present stage, human surrogate models of neuropathic pain are useful for the investigation of pharmacological mechanisms of action and therapeutic efficacy, because they are based on identical assessment techniques as in the actual patient studies." @default.
- W1571197042 created "2016-06-24" @default.
- W1571197042 creator A5071226824 @default.
- W1571197042 creator A5080703410 @default.
- W1571197042 date "2006-01-01" @default.
- W1571197042 modified "2023-10-02" @default.
- W1571197042 title "Chapter 33 Experimental human models of neuropathic pain" @default.
- W1571197042 cites W108060743 @default.
- W1571197042 cites W1579359120 @default.
- W1571197042 cites W1759966863 @default.
- W1571197042 cites W1808582964 @default.
- W1571197042 cites W1869612208 @default.
- W1571197042 cites W1968957793 @default.
- W1571197042 cites W1971340456 @default.
- W1571197042 cites W1975692268 @default.
- W1571197042 cites W1978286026 @default.
- W1571197042 cites W1979895609 @default.
- W1571197042 cites W1982119872 @default.
- W1571197042 cites W1986237413 @default.
- W1571197042 cites W1988468491 @default.
- W1571197042 cites W1990360679 @default.
- W1571197042 cites W1994443811 @default.
- W1571197042 cites W1994618304 @default.
- W1571197042 cites W1994705135 @default.
- W1571197042 cites W1997805756 @default.
- W1571197042 cites W2001452436 @default.
- W1571197042 cites W2003542915 @default.
- W1571197042 cites W2007560318 @default.
- W1571197042 cites W2022898812 @default.
- W1571197042 cites W2023752710 @default.
- W1571197042 cites W2024864390 @default.
- W1571197042 cites W2025360617 @default.
- W1571197042 cites W2025794199 @default.
- W1571197042 cites W2032752191 @default.
- W1571197042 cites W2033980432 @default.
- W1571197042 cites W2036459878 @default.
- W1571197042 cites W2038891610 @default.
- W1571197042 cites W2039840666 @default.
- W1571197042 cites W2039842671 @default.
- W1571197042 cites W2041091716 @default.
- W1571197042 cites W2044488313 @default.
- W1571197042 cites W2045339691 @default.
- W1571197042 cites W2046017277 @default.
- W1571197042 cites W2048115706 @default.
- W1571197042 cites W2053084183 @default.
- W1571197042 cites W2053864414 @default.
- W1571197042 cites W2057439534 @default.
- W1571197042 cites W2062700118 @default.
- W1571197042 cites W2065823746 @default.
- W1571197042 cites W2066025380 @default.
- W1571197042 cites W2069718130 @default.
- W1571197042 cites W2071862338 @default.
- W1571197042 cites W2073223761 @default.
- W1571197042 cites W2074064333 @default.
- W1571197042 cites W2084688496 @default.
- W1571197042 cites W2085908934 @default.
- W1571197042 cites W2088862696 @default.
- W1571197042 cites W2094898453 @default.
- W1571197042 cites W2098605131 @default.
- W1571197042 cites W2098947546 @default.
- W1571197042 cites W2108197576 @default.
- W1571197042 cites W2110206401 @default.
- W1571197042 cites W2113651400 @default.
- W1571197042 cites W2118832863 @default.
- W1571197042 cites W2122778405 @default.
- W1571197042 cites W2125454594 @default.
- W1571197042 cites W2126855798 @default.
- W1571197042 cites W2127152798 @default.
- W1571197042 cites W2133316133 @default.
- W1571197042 cites W2134304608 @default.
- W1571197042 cites W2136477585 @default.
- W1571197042 cites W2136779819 @default.
- W1571197042 cites W2137215180 @default.
- W1571197042 cites W2138191097 @default.
- W1571197042 cites W2140910583 @default.
- W1571197042 cites W2141678708 @default.
- W1571197042 cites W2142807246 @default.
- W1571197042 cites W2155412494 @default.
- W1571197042 cites W2320465523 @default.
- W1571197042 cites W2412769083 @default.
- W1571197042 cites W4366807463 @default.
- W1571197042 doi "https://doi.org/10.1016/s0072-9752(06)80037-0" @default.
- W1571197042 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18808855" @default.
- W1571197042 hasPublicationYear "2006" @default.
- W1571197042 type Work @default.
- W1571197042 sameAs 1571197042 @default.
- W1571197042 citedByCount "13" @default.
- W1571197042 countsByYear W15711970422014 @default.
- W1571197042 countsByYear W15711970422016 @default.
- W1571197042 countsByYear W15711970422017 @default.
- W1571197042 countsByYear W15711970422019 @default.
- W1571197042 countsByYear W15711970422020 @default.
- W1571197042 countsByYear W15711970422021 @default.
- W1571197042 countsByYear W15711970422022 @default.
- W1571197042 countsByYear W15711970422023 @default.
- W1571197042 crossrefType "book-chapter" @default.
- W1571197042 hasAuthorship W1571197042A5071226824 @default.
- W1571197042 hasAuthorship W1571197042A5080703410 @default.