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• W1571244423 abstract "Abstract Backbone degradable, linear, multiblock N ‐(2‐hydroxypropyl)methacrylamide (HPMA) copolymer–doxorubicin (DOX) conjugates are synthesized by reversible addition–fragmentation chain transfer (RAFT) polymerization followed by chain extension via thiol‐ene click reaction. The examination of molecular‐weight‐dependent antitumor activity toward human ovarian A2780/AD carcinoma in nude mice reveals enhanced activity of multiblock, second‐generation, higher molecular weight conjugates when compared with traditional HPMA copolymer–DOX conjugates. The examination of body weight changes during treatment indicates the absence of non‐specific adverse effects. magnified image" @default.
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• W1571244423 date "2013-01-22" @default.
• W1571244423 modified "2023-10-18" @default.
• W1571244423 title "Synthesis of Long-Circulating, Backbone Degradable HPMA Copolymer-Doxorubicin Conjugates and Evaluation of Molecular-Weight-Dependent Antitumor Efficacy" @default.
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• W1571244423 doi "https://doi.org/10.1002/mabi.201200353" @default.
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