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- W1571277229 abstract "BACKGROUND: Human umbilical tissue-derived cells (hUTC) represent a promising source of cells for regenerative treatment of stroke. OBJECTIVE: In this study, we tested the efficacy of hUTC in experimental stroke and whether multiple injections of hUTC provide any additional benefits as compared to a single injection. DESIGN/METHODS: Adult male Wistar rats were subjected to 2 hours of middle cerebral artery occlusion (MCAo), and randomly selected animals were injected (i.v) with 3x10 6 hUTC or with vehicle control (at 1, 1&3 or 1&7 days after MCAo, n=8-9/group). To test whether hUTC treatment of stroke regulates functional outcome, a battery of functional tests, consisting of adhesive-removal test, modified Neurological Severity Score (mNSS) and foot-fault test, was performed at day 1 (before treatment) and at 7, 14, 21, 28, 35, 42, 49, 56 and 63 days after MCAo. Rats were sacrificed at 63 days after MCAo and lesion volumes were measured using H&E. To assess whether hUTC cell treatment promotes angiogenesis and synaptogenesis, immunohistochemical stainings for Von Willebrand Factor (vWF), and Synaptophysin were performed. RESULTS: All hUTC treated groups, single or multiple injections, had better functional recovery compared to control (p 0.07) in functional outcome. All hUTC treatment groups showed significant increases in Synaptophysin expression, vascular density and perimeters in the ischemic boundary zone (IBZ), compared to the control group (p 0.1). CONCLUSIONS: hUTC treatment significantly improves long term functional outcome after stroke and increases vascular density, perimeters and synaptic plasticity in the ischemic brain. Multiple injections of hUTC were not superior to single injection therapy in both functional outcome and histological assessments. Study Supported by: Advanced Technologies and Regenerative Medicine, LLC. Disclosure: Dr. Shehadah has nothing to disclose. Dr. Chen has nothing to disclose. Dr. Kramer has received personal compensation for activities with Advanced Technologies and Regenerative Medicine. Dr. Kramer has received research support from Advanced Technologies and Regenerative Medicine. Dr. Zacharek has nothing to disclose. Dr. Cui has nothing to disclose. Dr. Roberts has nothing to disclose. Dr. Lu has nothing to disclose. Dr. Chopp has received personal compensation for activities with EVER Pharmaceutical and Johnson & Johnson. Dr. Chopp has received license fee payments from RegenRx." @default.
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- W1571277229 date "2014-04-08" @default.
- W1571277229 modified "2023-09-24" @default.
- W1571277229 title "Efficacy of Single and Multiple Injections of Human Umbilical Tissue-Derived Cells Following Experimental Stroke in Rats (S45.007)" @default.
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