Matches in SemOpenAlex for { <https://semopenalex.org/work/W1571295965> ?p ?o ?g. }
- W1571295965 endingPage "25" @default.
- W1571295965 startingPage "15" @default.
- W1571295965 abstract "Hypoxia is a condition of low oxygen tension occurring in the tumor and negatively correlated with the progression of the disease. We studied the gene expression profiles of nine neuroblastoma cell lines grown under hypoxic conditions to define gene signatures that characterize hypoxic neuroblastoma. The l1-l2 regularization applied to the entire transcriptome identified a single signature of 11 probesets discriminating the hypoxic state. We demonstrate that new hypoxia signatures, with similar discriminatory power, can be generated by a prior knowledge-based filtering in which a much smaller number of probesets, characterizing hypoxia-related biochemical pathways, are analyzed. l1-l2 regularization identified novel and robust hypoxia signatures within apoptosis, glycolysis, and oxidative phosphorylation Gene Ontology classes. We conclude that the filtering approach overcomes the noisy nature of the microarray data and allows generating robust signatures suitable for biomarker discovery and patients risk assessment in a fraction of computer time." @default.
- W1571295965 created "2016-06-24" @default.
- W1571295965 creator A5000912737 @default.
- W1571295965 creator A5003964675 @default.
- W1571295965 creator A5029697054 @default.
- W1571295965 creator A5030374281 @default.
- W1571295965 creator A5036620304 @default.
- W1571295965 creator A5061220999 @default.
- W1571295965 creator A5083486899 @default.
- W1571295965 creator A5084890701 @default.
- W1571295965 creator A5087636326 @default.
- W1571295965 date "2010-04-01" @default.
- W1571295965 modified "2023-09-23" @default.
- W1571295965 title "Identification of Multiple Hypoxia Signatures in Neuroblastoma Cell Lines by l(1)-l(2) Regularization and Data Reduction" @default.
- W1571295965 cites W1480376833 @default.
- W1571295965 cites W1480400193 @default.
- W1571295965 cites W1493048246 @default.
- W1571295965 cites W1516161999 @default.
- W1571295965 cites W1554944419 @default.
- W1571295965 cites W1578283200 @default.
- W1571295965 cites W1848530711 @default.
- W1571295965 cites W1970832400 @default.
- W1571295965 cites W1981487137 @default.
- W1571295965 cites W1988999672 @default.
- W1571295965 cites W1990833827 @default.
- W1571295965 cites W1994409282 @default.
- W1571295965 cites W1997453445 @default.
- W1571295965 cites W1999132491 @default.
- W1571295965 cites W2010356452 @default.
- W1571295965 cites W2010386340 @default.
- W1571295965 cites W2011810742 @default.
- W1571295965 cites W2023799373 @default.
- W1571295965 cites W2025602075 @default.
- W1571295965 cites W2030494099 @default.
- W1571295965 cites W2069698188 @default.
- W1571295965 cites W2071143412 @default.
- W1571295965 cites W2071491707 @default.
- W1571295965 cites W2071792840 @default.
- W1571295965 cites W2072227408 @default.
- W1571295965 cites W2084939996 @default.
- W1571295965 cites W2095849686 @default.
- W1571295965 cites W2103017472 @default.
- W1571295965 cites W2104353859 @default.
- W1571295965 cites W2107956883 @default.
- W1571295965 cites W2109972881 @default.
- W1571295965 cites W2114147096 @default.
- W1571295965 cites W2122825543 @default.
- W1571295965 cites W2128114973 @default.
- W1571295965 cites W2132374537 @default.
- W1571295965 cites W2140192325 @default.
- W1571295965 cites W2142354018 @default.
- W1571295965 cites W2145096794 @default.
- W1571295965 cites W2157952351 @default.
- W1571295965 cites W2160188982 @default.
- W1571295965 cites W2160821900 @default.
- W1571295965 cites W2163293935 @default.
- W1571295965 cites W2165374837 @default.
- W1571295965 cites W2171524340 @default.
- W1571295965 cites W2327522594 @default.
- W1571295965 hasPublicationYear "2010" @default.
- W1571295965 type Work @default.
- W1571295965 sameAs 1571295965 @default.
- W1571295965 citedByCount "1" @default.
- W1571295965 countsByYear W15712959652014 @default.
- W1571295965 crossrefType "journal-article" @default.
- W1571295965 hasAuthorship W1571295965A5000912737 @default.
- W1571295965 hasAuthorship W1571295965A5003964675 @default.
- W1571295965 hasAuthorship W1571295965A5029697054 @default.
- W1571295965 hasAuthorship W1571295965A5030374281 @default.
- W1571295965 hasAuthorship W1571295965A5036620304 @default.
- W1571295965 hasAuthorship W1571295965A5061220999 @default.
- W1571295965 hasAuthorship W1571295965A5083486899 @default.
- W1571295965 hasAuthorship W1571295965A5084890701 @default.
- W1571295965 hasAuthorship W1571295965A5087636326 @default.
- W1571295965 hasConcept C104317684 @default.
- W1571295965 hasConcept C126322002 @default.
- W1571295965 hasConcept C150194340 @default.
- W1571295965 hasConcept C162317418 @default.
- W1571295965 hasConcept C178790620 @default.
- W1571295965 hasConcept C18431079 @default.
- W1571295965 hasConcept C185592680 @default.
- W1571295965 hasConcept C186836561 @default.
- W1571295965 hasConcept C20251656 @default.
- W1571295965 hasConcept C2776715637 @default.
- W1571295965 hasConcept C2779081379 @default.
- W1571295965 hasConcept C502942594 @default.
- W1571295965 hasConcept C509974204 @default.
- W1571295965 hasConcept C540031477 @default.
- W1571295965 hasConcept C54355233 @default.
- W1571295965 hasConcept C55493867 @default.
- W1571295965 hasConcept C60644358 @default.
- W1571295965 hasConcept C62231903 @default.
- W1571295965 hasConcept C70721500 @default.
- W1571295965 hasConcept C71924100 @default.
- W1571295965 hasConcept C7836513 @default.
- W1571295965 hasConcept C81885089 @default.
- W1571295965 hasConcept C8415881 @default.
- W1571295965 hasConcept C86803240 @default.