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- W1571303355 abstract "Publisher Summary This chapter discusses the metabolism and life span determination in Caenorhabditis elegans . Several mechanisms can extend longevity of C. elegans , including caloric restriction and single gene mutations notably in the Ins/IGF pathway and in any one of the clk genes. All of them affect metabolism, and it is important to establish the changes consistently associated with aging. Caloric restriction causes increases rather than decreases in metabolic rate, measured as respiration and heat production rates. Reduced Ins/IGF signaling does not affect respiration rates, however lowers heat dissipation and possibly CO 2 production. Mutation in any one of the clk genes deregulates, and on average slows down, a number of temporal processes, however does only mildly, at most, affect respiration and heat production rates. Longevity is generally associated with increased resistance to stress, particularly oxidative stress, which is also reflected by co-ordinated increases in catalase and superoxide dismutase (SOD) activities. Consistent up-regulation of these enzyme activities is not seen in clk mutants. Life extension by dietary restriction is independent of the Ins/IGF signaling pathway in C. elegans , like in the mouse." @default.
- W1571303355 created "2016-06-24" @default.
- W1571303355 creator A5022562919 @default.
- W1571303355 creator A5038673488 @default.
- W1571303355 creator A5052453987 @default.
- W1571303355 date "2003-01-01" @default.
- W1571303355 modified "2023-09-23" @default.
- W1571303355 title "Metabolism and life span determination in C. elegans" @default.
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