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- W1571382840 abstract "OBJECTIVE:To improve our understanding of Goal-directed behavior (GDB), we examined the neural basis of apathy in bvFTD by using a novel reaction time test that directly ascertains each component of GDB in patients and regression analyses to relate patterns of impairment on this task to regions of brain atrophy and white matter integrity.BACKGROUND: GDB is an essential facet of human activity, but the behavioral and biological mechanisms are not well understood. Apathy, one manifestation of impaired GDB, is perhaps the most common neuropsychiatric symptom associated with behavioral variant frontotemporal degeneration (bvFTD).DESIGN/METHODS: Eighteen subjects with bvFTD and 17 controls (NC) completed the Philadelphia Apathy Computerized Test (PACT). This test was designed to quantify each of the three components contributing to our model of GDB, including difficulty with initiation, limited planning and poor motivation. PACT scores were related to gray matter (GM) atrophy and reduced white matter fractional anisotropy (FA).RESULTS:Between-group comparisons found that apathetic bvFTD patients have slower latencies than NC on all three measures of the PACT: Initiation (t[33]=2.26, p<0.05; Planning (t[33]=4.79, p<0.001; Motivation (t[33]=2.17, p<0.05). Poor initiation was related to GM atrophy in anterior cingulate and reduced FA in cingulum. Planning impairment was related to GM atrophy in dorsolateral prefrontal cortex and reduced FA in superior longitudinal fasciculus. Poor motivation was related to GM atrophy in orbitofrontal cortex and reduced FA in uncinate fasciculus.CONCLUSIONS: Apathetic bvFTD patients have profound difficulty with initiation, planning and motivational aspects of GDB. These findings are consistent with the hypothesis that GDB encompasses three components supported by distinct prefrontal networks, and degradation of individual networks can lead to different patterns of GDB deficits in bvFTD.Study Supported by: John A. Hartford Foundation9s Building Academic Geriatric Nursing Capacity Award, US Public Health Service (F31NR013306, AG17586, AG15116, AG10124, NS53488 and NS44266), Wyncote Foundation. Disclosure: Dr. Massimo has nothing to disclose. Dr. Powers has nothing to disclose. Dr. Evans has nothing to disclose. Dr. Morgan has nothing to disclose. Dr. McMillan has nothing to disclose. Dr. Eslinger has nothing to disclose. Dr. Ersek has nothing to disclose. Dr. Grossman has received personal compensation for activities with Allon Therapeutics." @default.
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- W1571382840 date "2014-04-08" @default.
- W1571382840 modified "2023-10-05" @default.
- W1571382840 title "Neuroanatomy of Goal-Directed Behavior in Behavioral Variant Frontotemporal Degeneration (P3.224)" @default.
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