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- W1571586541 abstract "Publisher Summary This chapter discusses neoadjuvant hormonal therapy prior to radical prostatectomy. The goal of radical prostatectomy is complete removal of all cancer cells. Unfortunately, even in carefully selected patients, up to two-thirds of clinically confined tumors are understaged, and positive margin rates of 30–60% are reported following radical prostatectomy. Ideal candidates for radical prostatectomy are men with the highest probability of being cured by the operation. Cure rates following radical prostatectomy alone exceed 80% in men with low-risk tumors. High-risk tumors exhibit a more aggressive natural history and have higher positive margin and recurrence rates after radical prostatectomy or radiotherapy alone, where unimodality therapy likely represents undertreatment. Paradoxically, the therapeutic ratio (patients who actually realize a survival benefit from a therapeutic intervention) may, therefore, be greater in high-risk disease, if its natural history can be altered by multimodality therapy. It is important, therefore, to investigate therapies that optimize complete extirpation of all cancer cells and reduce the incidence of positive surgical margins and disease recurrence." @default.
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- W1571586541 title "Chapter 11 Neoadjuvant hormonal therapy prior to radical prostatectomy" @default.
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- W1571586541 doi "https://doi.org/10.1016/s1569-254x(99)80012-0" @default.
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