FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1571622978> ?p ?o ?g. }

• W1571622978 endingPage "3950" @default.
• W1571622978 startingPage "3945" @default.
• W1571622978 abstract "Abstract SMADs are evolutionarily conserved transducers of the differentiation and growth arrest signals from the transforming growth factor/BMP (TGF/BMP) family of ligands. Upon receptor activation, the ligand-restricted SMADs1–35 are phosphorylated in the C-terminal MH2 domain and recruit the common subunit SMAD4/DPC-4 gene to the nucleus to mediate target gene expression. Frequent inactivating mutations of SMAD4, or less common somatic mutations ofSMAD2 seen in solid tumors, suggest that these genes have a suppressor function. However, there have been no identified mutations of SMAD5, although the gene localizes to the critical region of loss in chromosome 5q31.1 (chromosome 5, long arm, region 3, band 1, subband 1) in myelodysplasia (MDS) and acute myelogenous leukemia (AML). A ubiquitously expressed novel isoform,SMAD5β, encodes a 351 amino acid protein with a truncated MH2 domain and a unique C-terminal tail of 18 amino acids, which may be the functional equivalent of inactivating mutations. The levels of SMAD5β transcripts are higher in the undifferentiated CD34+ hematopoietic stem cells than in the terminally differentiated peripheral blood leukocytes, thereby implicating the β form in stem cell homeostasis. Yeast 2-hybrid interaction assays reveal the lack of physical interactions between SMAD5β and SMAD5 or SMAD4. The expression ofSMAD5β may represent a novel mechanism to protect pluripotent stem cells and malignant cells from the growth inhibitory and differentiation signals of BMPs." @default.
• W1571622978 created "2016-06-24" @default.
• W1571622978 creator A5009852060 @default.
• W1571622978 creator A5048910712 @default.
• W1571622978 creator A5054273270 @default.
• W1571622978 creator A5061580583 @default.
• W1571622978 creator A5077900290 @default.
• W1571622978 date "2000-06-15" @default.
• W1571622978 modified "2023-10-11" @default.
• W1571622978 title "Differential expression of a novel C-terminally truncated splice form of SMAD5 in hematopoietic stem cells and leukemia" @default.
• W1571622978 cites W1494055834 @default.
• W1571622978 cites W1529816420 @default.
• W1571622978 cites W1589859980 @default.
• W1571622978 cites W1663371441 @default.
• W1571622978 cites W1672956489 @default.
• W1571622978 cites W1964269746 @default.
• W1571622978 cites W1972124518 @default.
• W1571622978 cites W1985929046 @default.
• W1571622978 cites W1991110432 @default.
• W1571622978 cites W2003700848 @default.
• W1571622978 cites W2007444505 @default.
• W1571622978 cites W2041750289 @default.
• W1571622978 cites W2045776241 @default.
• W1571622978 cites W2060624116 @default.
• W1571622978 cites W2065939130 @default.
• W1571622978 cites W2082466352 @default.
• W1571622978 cites W2094579915 @default.
• W1571622978 cites W2100522747 @default.
• W1571622978 cites W2102868284 @default.
• W1571622978 cites W2103031848 @default.
• W1571622978 cites W2105735700 @default.
• W1571622978 cites W2118199431 @default.
• W1571622978 cites W2132008353 @default.
• W1571622978 cites W2142250806 @default.
• W1571622978 cites W2162141795 @default.
• W1571622978 cites W2162238950 @default.
• W1571622978 cites W2267684685 @default.
• W1571622978 cites W2314951634 @default.
• W1571622978 cites W72367593 @default.
• W1571622978 doi "https://doi.org/10.1182/blood.v95.12.3945" @default.
• W1571622978 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10845932" @default.
• W1571622978 hasPublicationYear "2000" @default.
• W1571622978 type Work @default.
• W1571622978 sameAs 1571622978 @default.
• W1571622978 citedByCount "19" @default.
• W1571622978 countsByYear W15716229782012 @default.
• W1571622978 countsByYear W15716229782013 @default.
• W1571622978 countsByYear W15716229782015 @default.
• W1571622978 countsByYear W15716229782016 @default.
• W1571622978 countsByYear W15716229782018 @default.
• W1571622978 countsByYear W15716229782021 @default.
• W1571622978 countsByYear W15716229782022 @default.
• W1571622978 crossrefType "journal-article" @default.
• W1571622978 hasAuthorship W1571622978A5009852060 @default.
• W1571622978 hasAuthorship W1571622978A5048910712 @default.
• W1571622978 hasAuthorship W1571622978A5054273270 @default.
• W1571622978 hasAuthorship W1571622978A5061580583 @default.
• W1571622978 hasAuthorship W1571622978A5077900290 @default.
• W1571622978 hasConcept C104317684 @default.
• W1571622978 hasConcept C107459253 @default.
• W1571622978 hasConcept C109159458 @default.
• W1571622978 hasConcept C127716648 @default.
• W1571622978 hasConcept C145103041 @default.
• W1571622978 hasConcept C148738053 @default.
• W1571622978 hasConcept C153911025 @default.
• W1571622978 hasConcept C28328180 @default.
• W1571622978 hasConcept C501734568 @default.
• W1571622978 hasConcept C502942594 @default.
• W1571622978 hasConcept C54355233 @default.
• W1571622978 hasConcept C68838962 @default.
• W1571622978 hasConcept C86803240 @default.
• W1571622978 hasConcept C95444343 @default.
• W1571622978 hasConceptScore W1571622978C104317684 @default.
• W1571622978 hasConceptScore W1571622978C107459253 @default.
• W1571622978 hasConceptScore W1571622978C109159458 @default.
• W1571622978 hasConceptScore W1571622978C127716648 @default.
• W1571622978 hasConceptScore W1571622978C145103041 @default.
• W1571622978 hasConceptScore W1571622978C148738053 @default.
• W1571622978 hasConceptScore W1571622978C153911025 @default.
• W1571622978 hasConceptScore W1571622978C28328180 @default.
• W1571622978 hasConceptScore W1571622978C501734568 @default.
• W1571622978 hasConceptScore W1571622978C502942594 @default.
• W1571622978 hasConceptScore W1571622978C54355233 @default.
• W1571622978 hasConceptScore W1571622978C68838962 @default.
• W1571622978 hasConceptScore W1571622978C86803240 @default.
• W1571622978 hasConceptScore W1571622978C95444343 @default.
• W1571622978 hasIssue "12" @default.
• W1571622978 hasLocation W15716229781 @default.
• W1571622978 hasOpenAccess W1571622978 @default.
• W1571622978 hasPrimaryLocation W15716229781 @default.
• W1571622978 hasRelatedWork W1989367421 @default.
• W1571622978 hasRelatedWork W2057496292 @default.
• W1571622978 hasRelatedWork W2149641002 @default.
• W1571622978 hasRelatedWork W2804323293 @default.
• W1571622978 hasRelatedWork W2904738166 @default.
• W1571622978 hasRelatedWork W2946983779 @default.
• W1571622978 hasRelatedWork W3024970269 @default.
• W1571622978 hasRelatedWork W4309232485 @default.

• next