FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1571696288> ?p ?o ?g. }

• W1571696288 endingPage "384" @default.
• W1571696288 startingPage "374" @default.
• W1571696288 abstract "Sepsis is a systemic inflammatory response to infection and a major cause of morbidity and mortality. Sildenafil (SLD) is a selective and potent inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase PDE5. We aimed to investigate the protective effects of sildenafil on caecal ligation and puncture (CLP)-induced sepsis in rats. Four groups of rats were used, each composed of 10 rats: (i) 10 mg/kg SLD-treated CLP group; (ii) 20 mg/kg SLD-treated CLP group; (iii) CLP group; and (iv) sham-operated control group. A CLP polymicrobial sepsis model was applied to the rats. All groups were killed 16 h later, and lung, kidney and blood samples were analysed histopathologically and biochemically. Sildenafil increased glutathione (GSH) and decreased the activation of myeloperoxidase (MPO) and of lipid peroxidase (LPO) and levels of superoxide dismutase (SOD) in the septic rats. We observed a significant decrease in LPO and MPO and a decrease in SOD activity in the sildenafil-treated CLP rats compared with the sham group. In addition, 20 mg/kg sildenafil treatment in the sham-operated rats improved the biochemical status of lungs and kidneys. Histopathological analysis revealed significant differences in inflammation scores between the sepsis group and the other groups, except the CLP + sildenafil 10 mg/kg group. The CLP + sildenafil 20 mg/kg group had the lowest inflammation score. Sildenafil treatment decreased the serum tumour necrosis factor (TNF)-α level when compared to the CLP group. Our results indicate that sildenafil is a highly protective agent in preventing lung and kidney damage caused by CLP-induced sepsis via maintenance of the oxidant-anti-oxidant status and decrease in the level of TNF-α." @default.
• W1571696288 created "2016-06-24" @default.
• W1571696288 creator A5017561262 @default.
• W1571696288 creator A5020352482 @default.
• W1571696288 creator A5032502889 @default.
• W1571696288 creator A5040299974 @default.
• W1571696288 creator A5043261050 @default.
• W1571696288 creator A5072827274 @default.
• W1571696288 creator A5077770674 @default.
• W1571696288 creator A5079058891 @default.
• W1571696288 creator A5088137730 @default.
• W1571696288 date "2011-11-08" @default.
• W1571696288 modified "2023-09-26" @default.
• W1571696288 title "Sildenafil treatment attenuates lung and kidney injury due to overproduction of oxidant activity in a rat model of sepsis: a biochemical and histopathological study" @default.
• W1571696288 cites W1500036760 @default.
• W1571696288 cites W1901731738 @default.
• W1571696288 cites W1963994658 @default.
• W1571696288 cites W1970919362 @default.
• W1571696288 cites W1977905350 @default.
• W1571696288 cites W1978968988 @default.
• W1571696288 cites W1983310681 @default.
• W1571696288 cites W1984025588 @default.
• W1571696288 cites W1989314933 @default.
• W1571696288 cites W1994246619 @default.
• W1571696288 cites W1995619154 @default.
• W1571696288 cites W1996659057 @default.
• W1571696288 cites W1997051387 @default.
• W1571696288 cites W2000386748 @default.
• W1571696288 cites W2003414772 @default.
• W1571696288 cites W2003578457 @default.
• W1571696288 cites W2016305001 @default.
• W1571696288 cites W2016497871 @default.
• W1571696288 cites W2020358486 @default.
• W1571696288 cites W2024295698 @default.
• W1571696288 cites W2024358287 @default.
• W1571696288 cites W2026084975 @default.
• W1571696288 cites W2026900256 @default.
• W1571696288 cites W2027202120 @default.
• W1571696288 cites W2028170967 @default.
• W1571696288 cites W2032387343 @default.
• W1571696288 cites W2035054847 @default.
• W1571696288 cites W2040049519 @default.
• W1571696288 cites W2044695093 @default.
• W1571696288 cites W2044860420 @default.
• W1571696288 cites W2047549421 @default.
• W1571696288 cites W2047623201 @default.
• W1571696288 cites W2049556543 @default.
• W1571696288 cites W2055744632 @default.
• W1571696288 cites W2057065126 @default.
• W1571696288 cites W2063576996 @default.
• W1571696288 cites W2065139599 @default.
• W1571696288 cites W2065672943 @default.
• W1571696288 cites W2067338751 @default.
• W1571696288 cites W2076520539 @default.
• W1571696288 cites W2080053658 @default.
• W1571696288 cites W2081792021 @default.
• W1571696288 cites W2083631490 @default.
• W1571696288 cites W2089552798 @default.
• W1571696288 cites W2093799856 @default.
• W1571696288 cites W2104091147 @default.
• W1571696288 cites W2115829876 @default.
• W1571696288 cites W2127312355 @default.
• W1571696288 cites W2129501902 @default.
• W1571696288 cites W2129952679 @default.
• W1571696288 cites W2141782268 @default.
• W1571696288 cites W2151272921 @default.
• W1571696288 cites W2151517451 @default.
• W1571696288 cites W2154072539 @default.
• W1571696288 cites W2159305277 @default.
• W1571696288 cites W2160314446 @default.
• W1571696288 cites W2168793993 @default.
• W1571696288 cites W2170003167 @default.
• W1571696288 cites W2204478813 @default.
• W1571696288 doi "https://doi.org/10.1111/j.1365-2249.2011.04483.x" @default.
• W1571696288 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3232386" @default.
• W1571696288 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22059996" @default.
• W1571696288 hasPublicationYear "2011" @default.
• W1571696288 type Work @default.
• W1571696288 sameAs 1571696288 @default.
• W1571696288 citedByCount "63" @default.
• W1571696288 countsByYear W15716962882012 @default.
• W1571696288 countsByYear W15716962882013 @default.
• W1571696288 countsByYear W15716962882014 @default.
• W1571696288 countsByYear W15716962882015 @default.
• W1571696288 countsByYear W15716962882016 @default.
• W1571696288 countsByYear W15716962882017 @default.
• W1571696288 countsByYear W15716962882018 @default.
• W1571696288 countsByYear W15716962882019 @default.
• W1571696288 countsByYear W15716962882020 @default.
• W1571696288 countsByYear W15716962882021 @default.
• W1571696288 countsByYear W15716962882022 @default.
• W1571696288 countsByYear W15716962882023 @default.
• W1571696288 crossrefType "journal-article" @default.
• W1571696288 hasAuthorship W1571696288A5017561262 @default.
• W1571696288 hasAuthorship W1571696288A5020352482 @default.
• W1571696288 hasAuthorship W1571696288A5032502889 @default.
• W1571696288 hasAuthorship W1571696288A5040299974 @default.
• W1571696288 hasAuthorship W1571696288A5043261050 @default.

• next