Matches in SemOpenAlex for { <https://semopenalex.org/work/W1571729775> ?p ?o ?g. }
- W1571729775 endingPage "956" @default.
- W1571729775 startingPage "949" @default.
- W1571729775 abstract "Cigarette smoking seems to be associated with prostate cancer (PCa) incidence and mortality. To elucidate the association between pretreatment smoking status, cumulative smoking exposure, and time since smoking cessation and the risk of biochemical recurrence (BCR) of PCa in patients treated with radical prostatectomy (RP). Retrospective analysis of 6538 patients with pathologically node-negative PCa treated with RP between 2000 and 2011. Clinicopathologic and smoking variables, including smoking status, number of cigarettes per day (CPD), duration in years, and time since smoking cessation were collected. RP without neoadjuvant therapy. Univariable and multivariable Cox regression analyses assessed the association between smoking and risk of PCa BCR. Of 6538 patients, 2238 (34%), 2086 (32%), and 2214 (34%) were never, former, and current smokers, respectively. Median follow-up for patients not experiencing BCR was 28 mo (interquartile range 14–42). RP Gleason score (p = 0.3), extracapsular extension (p = 0.2), seminal vesicle invasion (p = 0.8), and positive surgical margins (p = 0.9) were comparable among the three groups. In multivariable Cox regression analysis, former smokers (hazard ratio [HR] 1.63, 95% confidence interval [CI] 1.30–2.04; p < 0.001) and current smokers (HR 1.80, 95% CI 1.45–2.24; p < 0.001) had a higher risk of PCa BCR compared with non-smokers. Smoking cessation for ≥10 yr mitigated the risk of BCR in multivariable analyses (HR 0.96, 95% CI 0.68–1.37; p = 0.84). In multivariable analysis, no significant association between cumulative smoking exposure and risk of BCR could be detected. Limitations of the study include the retrospective design and potential recall bias regarding smoking history. Smoking seems to be associated with a higher risk of PCa BCR after RP. The effects of smoking appear to be mitigated by ≥10 yr of cessation. Smokers should be counseled regarding the detrimental effects of smoking on PCa prognosis. We investigated the effect of smoking on the risk of prostate cancer recurrence in patients with treated with surgery. We found that former smokers and current smokers were at higher risk of cancer recurrence compared to patients who never smoked; the detrimental effect of smoking was mitigated after 10 yr or more of smoking cessation. We conclude that smokers should be counseled regarding the detrimental effects on prostate cancer outcomes." @default.
- W1571729775 created "2016-06-24" @default.
- W1571729775 creator A5028444458 @default.
- W1571729775 creator A5029487621 @default.
- W1571729775 creator A5031550729 @default.
- W1571729775 creator A5044228660 @default.
- W1571729775 creator A5060993802 @default.
- W1571729775 creator A5064914239 @default.
- W1571729775 creator A5065748857 @default.
- W1571729775 creator A5067950171 @default.
- W1571729775 creator A5075113407 @default.
- W1571729775 creator A5076575190 @default.
- W1571729775 creator A5079401169 @default.
- W1571729775 creator A5079977409 @default.
- W1571729775 creator A5081063474 @default.
- W1571729775 date "2015-12-01" @default.
- W1571729775 modified "2023-10-16" @default.
- W1571729775 title "Association of Cigarette Smoking and Smoking Cessation with Biochemical Recurrence of Prostate Cancer in Patients Treated with Radical Prostatectomy" @default.
- W1571729775 cites W1968592303 @default.
- W1571729775 cites W1973004518 @default.
- W1571729775 cites W1983145936 @default.
- W1571729775 cites W2024275653 @default.
- W1571729775 cites W2028758612 @default.
- W1571729775 cites W2028807911 @default.
- W1571729775 cites W2043172028 @default.
- W1571729775 cites W2050671670 @default.
- W1571729775 cites W207737597 @default.
- W1571729775 cites W2102748070 @default.
- W1571729775 cites W2102917900 @default.
- W1571729775 cites W2128954898 @default.
- W1571729775 cites W2132018444 @default.
- W1571729775 cites W2132162604 @default.
- W1571729775 cites W2138073643 @default.
- W1571729775 cites W2147013342 @default.
- W1571729775 cites W2149617509 @default.
- W1571729775 cites W2156166860 @default.
- W1571729775 cites W2159657105 @default.
- W1571729775 cites W2164036061 @default.
- W1571729775 cites W2166618994 @default.
- W1571729775 cites W2252500925 @default.
- W1571729775 doi "https://doi.org/10.1016/j.eururo.2015.05.038" @default.
- W1571729775 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26050111" @default.
- W1571729775 hasPublicationYear "2015" @default.
- W1571729775 type Work @default.
- W1571729775 sameAs 1571729775 @default.
- W1571729775 citedByCount "45" @default.
- W1571729775 countsByYear W15717297752015 @default.
- W1571729775 countsByYear W15717297752016 @default.
- W1571729775 countsByYear W15717297752017 @default.
- W1571729775 countsByYear W15717297752018 @default.
- W1571729775 countsByYear W15717297752019 @default.
- W1571729775 countsByYear W15717297752020 @default.
- W1571729775 countsByYear W15717297752021 @default.
- W1571729775 countsByYear W15717297752022 @default.
- W1571729775 countsByYear W15717297752023 @default.
- W1571729775 crossrefType "journal-article" @default.
- W1571729775 hasAuthorship W1571729775A5028444458 @default.
- W1571729775 hasAuthorship W1571729775A5029487621 @default.
- W1571729775 hasAuthorship W1571729775A5031550729 @default.
- W1571729775 hasAuthorship W1571729775A5044228660 @default.
- W1571729775 hasAuthorship W1571729775A5060993802 @default.
- W1571729775 hasAuthorship W1571729775A5064914239 @default.
- W1571729775 hasAuthorship W1571729775A5065748857 @default.
- W1571729775 hasAuthorship W1571729775A5067950171 @default.
- W1571729775 hasAuthorship W1571729775A5075113407 @default.
- W1571729775 hasAuthorship W1571729775A5076575190 @default.
- W1571729775 hasAuthorship W1571729775A5079401169 @default.
- W1571729775 hasAuthorship W1571729775A5079977409 @default.
- W1571729775 hasAuthorship W1571729775A5081063474 @default.
- W1571729775 hasConcept C119060515 @default.
- W1571729775 hasConcept C121608353 @default.
- W1571729775 hasConcept C126322002 @default.
- W1571729775 hasConcept C126894567 @default.
- W1571729775 hasConcept C142724271 @default.
- W1571729775 hasConcept C143998085 @default.
- W1571729775 hasConcept C167135981 @default.
- W1571729775 hasConcept C207103383 @default.
- W1571729775 hasConcept C2777008409 @default.
- W1571729775 hasConcept C2777843972 @default.
- W1571729775 hasConcept C2779466945 @default.
- W1571729775 hasConcept C2780192828 @default.
- W1571729775 hasConcept C29456083 @default.
- W1571729775 hasConcept C44249647 @default.
- W1571729775 hasConcept C50382708 @default.
- W1571729775 hasConcept C71924100 @default.
- W1571729775 hasConceptScore W1571729775C119060515 @default.
- W1571729775 hasConceptScore W1571729775C121608353 @default.
- W1571729775 hasConceptScore W1571729775C126322002 @default.
- W1571729775 hasConceptScore W1571729775C126894567 @default.
- W1571729775 hasConceptScore W1571729775C142724271 @default.
- W1571729775 hasConceptScore W1571729775C143998085 @default.
- W1571729775 hasConceptScore W1571729775C167135981 @default.
- W1571729775 hasConceptScore W1571729775C207103383 @default.
- W1571729775 hasConceptScore W1571729775C2777008409 @default.
- W1571729775 hasConceptScore W1571729775C2777843972 @default.
- W1571729775 hasConceptScore W1571729775C2779466945 @default.
- W1571729775 hasConceptScore W1571729775C2780192828 @default.
- W1571729775 hasConceptScore W1571729775C29456083 @default.