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• W1571796127 abstract "Chinese hamster ovary (CHO) cells were synchronized by mitotic shake-off, treated with the fluorochrome acridine orange (AO; 0.5 μg/ml), washed free of excess dye and subsequently exposed to visible light (2 × 40 W/8 Wm−2). The light exposure was performed on cells in the G1, G1/S, S or G2 phase of the cell cycle. AO + light induced high frequencies of aberration in the S phase and even higher in the G1 phase. The abberations observed were all of the chromatid type. The chromosome-type aberrations (dicentrics, rings) obtained when cells in the G1 phase were exposed to X-rays were not found after corresponding treatments with AO + light. With the exception of an increased frequency of gaps, no chromosomal aberrations were induced in G2-phase cells. Sister-chromatid exchanges were effeciently produced by the photodynamic system in the G1, G1/S and S phase of the cell cycle. In other experiments, AO-treated unsynchronized CHO cells were exposed to light in the presence of the hydroxyl radical scavengers mannitol (100 mM) and 5-dimethyl thiourea (100 mM). In parallel experiments these scavengers were found to reduce markedly the chromosome breaking effects by X-rays but had no influence on the photodynamic induction of chromosomal alterations. The results presented show that the visible light-induced chromosomal alterations in CHO cells sensitized with the fluorochrome AO are obtained by an S-dependent mechanism. Furthermore, the results indicate that the hydroxyl free radicals does not play a major role in the production of chromosomal alterations by AO + light." @default.
• W1571796127 created "2016-06-24" @default.
• W1571796127 creator A5059049868 @default.
• W1571796127 date "1990-08-01" @default.
• W1571796127 modified "2023-09-27" @default.
• W1571796127 title "The induction of chromosomal aberrations and SCEs by visible light in combination with eyes" @default.
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• W1571796127 doi "https://doi.org/10.1016/0027-5107(90)90029-4" @default.
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