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- W1571911312 abstract "The portal vein drains blood from the small and large intestines, stomach, spleen, pancreas, and gallbladder. The superior mesenteric vein and the splenic vein unite behind the neck of the pancreas to form the portal vein. Normal portal pressure is generally defined between 5 and 10 mm Hg. An increase in the blood pressure to 12 mm Hg or greater, within a system of veins is called portal hypertension (PHT). The most common cause of portal hypertension is cirrhosis of the liver. Other causes include portal vein thrombosis and a parasitic infection by Schistosomiasis. Sometimes the cause is unknown. Portal hypertension leads to hemodynamic disturbances throughout the gastrointestinal tract. McCormack et al (1985) coined the term congestive gastropathy to represent the mucosal changes in gastric mucosa of patients with portal hypertension and distinguished it histologically from inflammatory gastritis. (McCormack et al., 1985) The entity was attributed to alteration in gastric microcirculation.( Sarfeh et al., 1987 & Tarnawaski et al., 1988).Initial reports mainly focused on portal hypertensive gastropathy which demonstrated endoscopic and histologic changes seen in the gastric mucosa.(Baxter & Dobbs, 1988; Corbishley et al.,1988; Foster et al.,1989; SP Misra et al., 1990; Papazian et al., 1986 & Triger & Hosking,1989)The entity was renamed as ‘portal hypertensive intestinal vasculopathy’ with the evidence of small intestinal and colonic involvement. (Kozarek et al., 1991; Thiruvengadam & Gostout, 1989 & Viggiano & Gostout, 1992). The term portal hypertensive colopathy was initially described in the 1990, as a poorly defined entity by Naveau et al. (1991) In patients with liver cirrhosis and portal hypertension, vascular changes in upper gastrointestinal tract in the form of varices of the esophagus, stomach and portal hypertensive gastropathy and enteropathy are well described. (V Misra et al., 1997, 1998 & SP Misra et al., 1990). In present chapter various aspects of changes in colonic mucosa of the patients with portal hypertension are described in detail." @default.
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- W1571911312 date "2011-08-29" @default.
- W1571911312 modified "2023-10-16" @default.
- W1571911312 title "Portal Hypertensive Colopathy" @default.
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- W1571911312 doi "https://doi.org/10.5772/21904" @default.
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